The efficacy of probiotics and vitamin D assisted montelukast sodium in the treatment of obese children with asthma and its effects on Th17/Treg,T-bet/GATA-3 expression,and leptin
Objective To investigate the effects and mechanisms of probiotics and vitamin D assisted montelukast sodium in the treatment of obese children with asthma.Methods A total of 90 obese asthmatic children were selected from the Pediatric Department of the 980th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from September 2020 to April2023,and were randomly divided into three groups of 30 cases each.All groups received conven-tional treatment with montelukast sodium,and on this basis,group 1 was given probiotics,group 2 was given vitamin D,and the observation group was given probiotics and vitamin D.Observe the efficacy and safety of the children,as well as the changes in lung function before and after treatment[percentage of forced expiratory volume in one second(FEV1%)pred,exhaled nitric oxide(FeNO),percentage of peakexpiratory flow(PEF%)pred],Th17/Treg cytokines[interleukin-10(IL-10),interleukin-6(IL-6),interleukin-17(IL-17)],T-box(T-bet)/GATA binding protein 3(GATA-3)expression of T cells,Th1/Th2 cytokines[interleukin-4(IL-4),interferon-gamma(IFN-γ),IFN-γ/IL-4],adipocytokines[leptin,adiponectin,serine pro-tease inhibitor(vaspin)].Results The total effective rate of the observation group was 100.00%,which was not signifi-cantly different from that of the control group 1 and control group 2(90.00%and 86.67%,respectively)(P>0.05);after treatment,the PEF%pred and FEV1%pred of the observation group were higher than those of the control group 1 and con-trol group 2(F/P=19.134/<0.001 and 9.613/<0.001),and FeNO,the serum levels of IL-6 and IL-17 were lower than those of the control group 1 and control group 2(F/P=14.069/<0.001,27.374/<0.001,45.591/<0.001),while the serum level of IL-10 was higher than that of the control group 1 and control group 2(F/P=58.689/<0.001);the T-bet and T-bet/GATA-3 levels were higher than those of the control group 1 and control group 2,while the GATA-3 level was lower than that of the con-trol group 1 and control group 2(F/P=14.137/<0.001,92.423/<0.001,13.984/<0.001);the serum levels of IFN-γ and IFN-γ/IL-4 were higher than those of the control group 1 and control group 2(F/P=103.381/<0.001 and 749.586/<0.001),while the serum level of IL-4 was lower than that of the control group 1 and control group 2(F/P=114.110/<0.001);there was no significant difference in the above indicators between the control group 1 and control group 2(all P>0.05);after treatment,the serum levels of leptin and vaspin in the observation group were lower than those of the control group 1 and control group 2(F/P=69.470/<0.001 and 17.835/<0.001),while the adiponectin level in the observation group was higher than that of the control group 1 and control group 2(F/P=47.148/<0.001).Conclusion Probiotics and vitamin D assisted monte-lukast sodium treatment can improve lung function in obese children with asthma,regulate adipocyte cytokines,T-bet/GA-TA-3 expression,Th1/Th2,and Th17/Treg cells,and have a definite therapeutic effect.
维普
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