Objective To investigate the Serum Growth Associated Protein-43(GAP-43)in Children with Epilepsy α-Synaptic nuclear protein(α-Syn)level,analyze the diagnostic value of both for pediatric epilepsy.Methods Eighty ped-iatric epilepsy patients diagnosed and treated in the Pediatric Department of Linfen People's Hospital from April2019 to April 2022 were included as the epilepsy group,50 children with syncope were included as the syncope group,and 50 children with inguinal hernia were included as the control group.Detection of serum GAP-43 using enzyme-linked immunosorbent as-say α-Syn level.Compare the differences in serum GAP-43 levels among three groups of children with epilepsy and different clinical features α-Differences in Syn levels.Pearson correlation analysis of serum GAP-43 α-The correlation between Syn and seizure severity scale score(NHS3).The diagnostic value of serum GAP-43,α-Syn and combination in pediatric epilepsy were analyzed by the receiver operating characteristic curve.Results Serum GAP-43 levels in epilepsy group<syncope group<control group,serum α-Syn level epilepsy group>syncope group>control group(F/P=821.793/<0.001,419.176/<0.001);The serum GAP-43 levels in children with epilepsy were elevated in patients with focal seizures and no cognitive im-pairment(t/P=8.745/<0.001,10.070/<0.001),α-Syn levels decreased in patients with focal seizures and no cognitive impair-ment(t/P=4.236/<0.001,14.881/<0.001),and there was no statistically significant difference between the two in terms of gender,age,abnormal electroencephalogram,and abnormal head MR(P>0.05);The serum GAP-43 levelis significantly neg-atively correlated with NHS3 score(r/P=-0.645/<0.001),and the serum α-The level of Syn is significantly positively corre-lated with NHS3 score(r/P=0.702/<0.001);Serum GAP-43 α-The AUC of Syn and two combined predictions for pediatric epilepsy were 0.740,0.738,and 0.835,respectively.The AUC of the two combined predictions was higher than that of the single prediction(Z=4.482 and 4.391,P<0.001).Conclusion The serum GAP-43 in children with epilepsy decreases,α-The elevated level of Syn is related to the type of epilepsy and cognitive impairment,and the combination of the two has high diagnostic value for pediatric epilepsy.
Pediatric epilepsyGrowth related protein 43α-Synaptic NucleoproteinDiagnosis
维普
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