Analysis of the therapeutic effect of blood perfusion combined with naloxone hydrochloride in the treatment of pa-tients with acute severe sedative drug poisoning
Objective To observe the clinicalefficacy of blood perfusion combined with naloxone hydrochloride in the treatment of patients with acute severe sedative drug poisoning.Methods One hundred and twenty patients with a-cute severe sedative drug poisoning treated in the Emergency Department of Changzhi People's Hospital from July 2019 to July 2023 were selected as the study subjects.Divide into a control group and a study group using a randomnumber table method,with 60 cases in each group.The control group received intravenous infusion of naloxone hydrochloride,while the study group received hemoperfusion treatment on the basis of the control group.Compare the clinical efficacy,wakefulness time,disappearance time of toxic symptoms,length of hospital stay,blood gas indexlevels[pH,arterial oxygen pressure(PaO2),arterial carbon dioxide pressure(PaCO2)],serum inflammatory factor levels[interleukin-4(IL-4),IL-6,tumor necrosis factor-α(TNF-α)]And the incidence of complications.Results The total clinical effective rate of the research group was 93.33%,higher than 76.67%in the control group(χ2/P=6.536/0.011).After treatment,the patients in the study group had shorter periods of consciousness,disappearance of toxic symptoms,and hospital stay compared to the control group(t/P= 6.675/<0.001,6.004/<0.001,7.174/<0.001).Compared with before treatment,the PaCO2,IL-4,IL-6,TNF-α of patients after treatment were decreased,and pH,PaO2 increased(P<0.05),and the decrease/increase amplitude in the study group was greater than that in the control group(t/P=6.745/<0.001,5.729/<0.001,6.922/<0.001,6.169/<0.001,2.419/0.017,4.291/<0.001).The total incidence of complications in the study group after treatment was 3.33%,lower than the 15.00%in the con-trol group(χ2/P=4.904/0.027).Conclusion Hemoperfusion combined with naloxone hydrochloride can effectively improve blood gas status,reduce inflammatory reactions,and promote patient recovery in patients with acute severe sedative drug poisoning.
Acute severe sedative drug poisoningBlood perfusionNaloxone hydrochlorideClinical efficacyIn-flammatory factors
维普
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