Objective To analyze the relationship between the expression of polypyrimidine binding protein 3(PT-BP3),ubiquitin specific protease 28(USP28)and postoperative recurrence and metastasis in elderly breast cancer.Methods From February 2017 to February 2020,178 elderly breast cancer patients were diagnosed and treated in the Breast Surgery Department of Liaoning Cancer Hospital.Detect the expression of PTBP3 and USP28 in tissues using immunohistochemistry.Follow up for3 years,Kaplan Meier survival analysis showed that different expressions of PTBP3 and USP28 had an impact on the recurrence and metastasis of elderly breast cancer after surgery.Coxregression analysis of factors influencing post-operative recurrence and metastasis of elderly breast cancer.Results The positive rates of PTBP3 and USP28 in breast cancer tissues were 65.17%(116/178)and 67.42%(120/178),higher than those in adjacent tissues 12.92%(23/178)and 11.24%(20/178),with a statistically significant difference(χ2=102.080,117.725,both P<0.001).The positive rates of PTBP3 and USP28 in TNM stage Ⅲ and moderately and poorly differentiated breast cancer tissues were higher than those in TNM stage Ⅱ and highly differentiated breast cancer tissues,and the differences were statistically significant(χ2/P=9.822/0.002,14.606/0.001,8.337/0.004,28.925/<0.001).The 3-year no recurrence and metastasis rate in the PTBP3 positive group was 70.43%(81/115),lower than the 93.55%(58/62)in the negative group(Log Rankχ2=12.521,P<0.001).The 3-year recurrence and metastasis free rate in the USP28 positive group was 72.27%(86/119),lower than the 91.38%(53/58)in the negative group(Log Rank χ2=8.511,P=0.003).Coxregression analysis showed that PTBP3 positive,USP28 positive,tumor stage Ⅲ,and medium and low differentiation were independent risk factors for postoperative recurrence and metastasis of breast cancer patients[OR(95%CI)=1.502(1.054-2.142),1.642(1.107-2.435),1.523(1.147-2.024),1.513(1.159-1.975),all P<0.05].Conclusion The increased expression of PTBP3 and USP28 in elderly breast cancer tissues,PTBP3 positive and USP28 positive are risk factors for postoperative recurrence and metastasis of elderly breast cancer patients.
Breast cancerPolypyrimidine binding protein 3Ubiquitin specific protease 28Postoperative recur-rence and metastasis
维普
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