Objective To explore the value of serum interferon-γ(IFN-γ)and chitinase protein-40(YKL-40)in the early diagnosis of urinary tract infection after percutaneous nephrolithotomy(PCNL).Methods From May 2018 to May 2023,108 patients with PCNL who visited Beijing Jishuitan Hospital Guizhou Hospital were collected as the study subjects.They were separated into an infected group(n=41)and an uninfected group(n=67)based on whether they had urinary tract infec-tion 24 hours after surgery.The clinical data of the two groups were compared;ELISA method was applied to detect and com-pare serum IFN and YKL-40 levels in two groups;Pearson method was applied to analyze the correlation between serum IFN and YKL-40 levels and indicators of urinary tract infection in patients with urinary tract infection after PCNL;Logistic regres-sion was applied to analyze the influencing factors of urinary tract infections after PCNL;receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum IFN and YKL-40 levels for urinary tract infections after PC-NL.Results The operation time,the proportion of history of diabetes and the proportion of renal insufficiency in the infected group were obviously higher than those in the uninfected group[(t(χ2)/P=4.356/0.037,5.016/0.025,8.682/0.003)];the levels of serum IFN and YKL-40 in the infected group were obviously higher than those in the uninfected group(t/P=7.276/<0.001,7.161/<0.001);Pearson correlation analysis showed that there was a positive correlation between serum IFN and YKL-40 levels in patients with urinary tract infection after PCNL(P<0.05);Logistic regression analysis showed that serum IFN-γ levels were positively correlated with WBC and CRP,PCT,IL-6,and TNF-αlevels in patients with urinary tract infections complicated by PCNL(r/P=0.251/0.025,0.428/0.004,0.584/<0.001,0.632/<0.001,0.374/0.008),and YKL-40 levels were positively correlated with WBC and CRP,PCT,IL-6,and TNF-α levels(r/P=0.603/<0.001,0.459/0.002,0.538/<0.001,0.474/<0.001,0.346/0.019);Logistic regression analysis showed that elevated levels of IFN-γand YKL-40 were independent risk factors affecting the complication of urinary tract infections after PCNL[OR(95%CI)=1.602(1.175-2.184),1.665(1.207-2.296)];ROC curve analysis results showed that the area under the curve(AUC)of serum IFN and YKL-40 levels alone and in combination for the diagnosis of PCNL complicated with urinary tract infections was 0.788,0.782,and 0.877,respectively,the combined diagnostic effect of the two was better than that of single diagnosis(Z/P=2.114/0.035,2.747/0.006).Conclusion The serum levels of IFN-γ and YKL-40 in patients with urinary tract infection after PCNL obviously increase,and the combined detection of the two has high diag-nostic value for urinary tract infection after PCNL.
Percutaneous nephrolithotomyUrinary tract infectionSerum interferon-γChitinase like protein-40Di-agnostic value
维普
万方数据
