Objective To explore the correlation between levels of fatty acid oxidation and pro lipolytic mediators and penile erectile dysfunction.Methods Seventy patients with erectile dysfunction treated at the Urology Center of the First Affiliated Hospital of Xinjiang Medical University from October 2022 to April 2023 were selected as the observation group,and an additional70 healthy males during the same period were selected as the healthy control group.Compare the general clinical data,serum testosterone(T),erectile hardness score(EHS),maximum systolic blood flow velocity(PSV)of u-nilateral penile artery,serum lipid peroxidation(LPO),expression levels of vasopressin D1(RvD1)and vasopressin E1(RvE1)between two groups of subjects.Screening for risk factors for erectile dysfunction through correlation analysis and multiva-riate logistic regression analysis.Further evaluate the predictive value of various risk factors for the occurrence of erectile dysfunction through receiver operating characteristic curve(ROC)and area under curve(AUC).Results The average ser-um LPO of the observation group patients was significantly higher than that of the healthy control group(t/P=8.714/<0.001),while RvD1,RvE1,EHS scores,and PSV levels were significantly lower than those of the healthy control group(t/P= 10.109/<0.001,10.410/<0.001,6.271/<0.001,13.243/<0.001);Pearson correlation analysis showed that serum LPO levels were negatively correlated with EHS and PSV(r/P=-0.275/0.033,-0.233/0.049),while RvD1 and RvE1 levels were positive-ly correlated with EHS and PSV(r/P=0.391/<0.001,0.366/<0.001,0.423/<0.001,0.387/<0.001);Multivariate logistic regres-sion analysis showed that elevated serum LPO levels were independent risk factors for the occurrence of erectile dysfunc-tion[OR(95%CI)=1.127(1.045-1.216)],and elevated levels of RvD1 and RvE1 were protective factors for the occurrence of erectile dysfunction[OR(95%CI)=0.761(0.669-0.866),0.787(0.707-0.876)];ROC curve analysis shows that serum LPO,RvD1,and RvE1 have high predictive power for the occurrence of erectile dysfunction,and their combined predictive value for disease is higher than the independent predictive value of each indicator(Z/P=1.873/0.013,1.803/0.019,1.711/0.033).Conclusion Elevated levels of serum fatty acid oxidation and decreased levels of pro lipolytic mediators are risk fac-tors for the occurrence of erectile dysfunction,providing new ideas for further exploration of the mechanisms underlying the occurrence and development of erectile dysfunction.
维普
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