Helicobacter pylori is a chronic infectious pathogen with a high infection rate worldwide,which is related to the occurrence of many diseases inside and outside the stomach.Currently,the specific pathogenic mechanism of H.py-lori associated gastritis(HAG)is not fully understood,and some reasons are related to the stimulation of multiple cytokines in the body after H.pylori infection.Cytokines play an important role in controlling infection and maintaining the develop-ment of chronic inflammatory response.Analyzing the cytokine response during H.pylori infection is key to understanding how gastric inflammatory response is regulated and is related to pathology and disease outcomes.The article provides a re-view of the research progress on cytokines involved in HAG.