Type 2 diabetes is one of the fastest growing metabolic diseases in the world.It is predicted that the number of diabetes patients will increase to 642 million by 2040,of which 30%～40%will develop into diabetes nephropa-thy.Insulin-like growth factor-1(IGF-1)is a peptide composed of 70 amino acids,which is homologous to insulin and has insulin-like effects.It also plays an important role in cell proliferation,differentiation,apoptosis,metabolism,embryonic devel-opment,tumor occurrence,and development.In recent years,many studies have found that IGF-1 directly or indirectly par-ticipates in the pathophysiological process of diabetes,and is closely related to the occurrence and development of diabetes nephropathy through insulin related signaling pathways.Cyclic glycine proline(cGP)is a metabolite of IGF-1 and partici-pates in the regulation of IGF-1.cGP/IGF-1 represents the biologically active IGF-1.This article reviews the possible role of IGF-1 in type 2 diabetes and type 2 diabetes nephropathy,and provides new ideas for its treatment and prevention.
Type 2 diabetesDiabetic nephropathyInsulin-like growth factor-1Cyclic glycine proline
维普
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