Relationship between changes in serum interleukin-12p70 and amyloid A levels and concomitant coronary heart dis-ease in patients with chronic obstructive pulmonary disease
Objective To analyze the changes of serum interleukin-12p70(IL-12p70)and amyloid A(SAA)levels in patients with chronic obstructive pulmonary disease(COPD)and their relationship with concomitant coronary heart dis-ease(CHD).Methods One hundred and fifty COPD patients diagnosed and treated in the Department of Respiratory and Critical Care Medicine,Fenyang Hospital,Shanxi Medical University,were selected from May 2019 to May 2023,among which 58 patients with concurrent CHD were included in the COPD-CHD group,and 92 patients without concurrent CHD were included in the COPD group.Serum IL-12p70 and SAA levels were detected;the incidence of concurrent CHD in COPD patients with different serum IL-12p70 and SAA levels was compared;logistic regression modeling was used to ana-lyze the independent relationship between serum IL-12p70 and SAA and concurrent CHD in COPD patients,and subjects'work characteristic curves(ROC curves)were used to analyze serum IL-12p70,the value of SAA in predicting the complica-tion of CHD in COPD patients.Results The proportion of smoking history,proportion of diabetes,fibrinogen and serum IL-12p70,SAA levels in COPD-CHD group were higher than those in COPD group[χ2(t)/P=4.696/0.030,4.801/0.029,2.629/0.010,6.111/<0.001,5.744/<0.001];with the increase of serum IL-12p70 and SAA levels,the incidence of concomitant CHD in patients with COPD showed a trend of increasing(χ2/P=27.864/<0.001,31.346/<0.001);elevated serum IL-12p70 and SAA were both independent risk factors for the complication of CHD in patients with COPD[OR(95%CI)=3.350(2.002-5.607),3.658(2.268-5.899)];ROC curve analysis showed that the AUC of serum IL-12p70 and SAA combined in predicting concurrent CHD in patients with COPD was 0.835,which was better than their respective individual predictive efficacy(Z/P=2.180/0.029,2.244/0.025).Conclusion Serum IL-12p70 and SAA levels were elevated in patients with COPD,especially in the presence of CHD,and both of them are independent risk factors for CHD in patients with COPD,and the risk of CHD in patients with COPD can be determined by the levels of these two indexes in clinical practice.
Chronic obstructive pulmonary diseaseCoronary heart diseaseInterleukin-12p70Amyloid A
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