Objective To investigate the expression significance of serum long non-coding ribonucleic acid(Ln-cRNA)FAF and inter alpha trypsin inhibitor heavy chain 4(ITIH4)in patients with chronic heart failure(CHF)and their prognostic value.Methods A total of 187 patients with CHF admitted to the Department of Emergency,the Second Affilia-ted Hospital of Anhui Medical University from January 2020 to January 2022 were selected as CHF group,and then divided into Grade Ⅱ subgroup(65 cases),grade Ⅲ subgroup(77 cases),and grade Ⅳ subgroup(45 cases)according to NYHA cardiac function classification.In the same period,103 healthy volunteers were recruited as control group.Serum LncRNA FAF expression and ITIH4 level were detected,and the incidence of major adverse cardiovascular events(MACE)during follow-up was analyzed for 12 months after discharge.Multivariate Logistic regression analysis was conducted to analyze the factors affecting the occurrence of MACE in CHF patients,and the value of LncRNA FAF and ITIH4 in predicting the occurrence of MACE in CHF patients was analyzed by receiver operating characteristic(ROC)curve.Results Serum Ln-cRNA FAF expression and ITIH4 level in CHF group were lower than those in control group(t/P=24.469/＜0.001,35.196/＜0.001).Serum LncRNA FAF expression and ITIH4 level in grade Ⅳ group were lower than those in grade Ⅲ and grade Ⅱgroups(F/P=91.653/＜0.001,102.345/＜0.001).Serum LncRNA FAF expression and ITIH4 level in MACE group were lower than those in non-MACE group(t/P=13.556/＜0.001,6.293/＜0.001).NYHA grade Ⅳ and high level of NT-pro BNP were risk factors for MACEin CHF patients,high expression of LncRNA FAF and high level of ITIH4 were protective factors[OR(95%CI)=4.627(2.245-9.538),2.284(1.505-3.468),0.599(0.425-0.844),0.666(0.478-0.928)].The area under the curve of LncRNA FAF,ITIH4 and combined detection in predicting the occurrence of MACE in CHF patients was 0.796,0.801 and 0.896,and the area under the curve of combined prediction was higher than that of single prediction(Z=2.453,2.404,all P＜0.001).Conclusion Serum LncRNA FAF expression and ITIH4 level are decreased in CHF patients,and are associated with poor prognosis.Combining LncRNA FAF and ITIH4 can predict the risk of poor prognosis in CHF patients.
维普
万方数据
