Objective To analyze the expression of serum osteocalcin and deacetylase 6(SIRT6)in patients with acute ischemic stroke(AIS)and their evaluation value for clinical prognosis.Methods Ninety AIS patients(AIS group)who treated in the Department of Neurology of People's Hospital Banan District from February 2019 to February 2021 were collected,90 patients with hypertension or diabetes treated at the same time were taken as the disease control group,and 90 healthy individuals were selected as the control group.Following up for 3 months,AIS patients were divided into a poor prognosis group(n=24)and a good prognosis group(n=66)based on their prognosis.Enzyme-linked immunosorbent as-say was used to detect serum osteocalcin and SIRT6 levels.Multivariate Logistic regression analysis was used to analyze factors affecting poor prognosis in AIS patients.The evaluation value of various indicators in evaluating the adverse prog-nosis of AIS patients through receiver operating curve analysis.Results Compared with the healthy control group,the se-rum levels of osteocalcin and SIRT6 decreased in the AIS group(t/P=25.013/＜0.001,27.571/＜0.001).Compared with the non AIS group,the AIS group showed a significant decrease(t/P=31.808/＜0.001,36.440/＜0.001),while there was no sta-tistically significant difference between the healthy control group and the non AIS group(t/P=2.559/0.152,3.113/0.067).The serum osteocalcin and SIRT6 levels in AIS patients in the severe,moderate,and mild subgroups decreased sequentially(F/P=15.234/＜0.001,30.388/＜0.001).Compared with the subgroup with good prognosis,AIS patients in the subgroup with poor prognosis have larger infarct size,higher NIHSS score,and lower serum osteocalcin and SIRT6(χ2/t=8.511,22.826,3.592,3.729,all P＜0.001).Large infarct size and high NIHSS score are independent risk factors for poor prognosis in AIS patients[OR(95%CI)=1.397(1.141-1.709),1.363(1.076-1.728)].Low serumosteocalcin and SIRT6 are independent pro-tective factors affecting the poor prognosis of AIS patients[OR(95%CI)=0.770(0.610-0.973),0.709(0.549-0.915)].The AUC of serum osteocalcin,SIRT6,and their combination for adverse prognosis in AIS patients were 0.782,0.796,and 0.886,respectively.The combined AUC of the two items was greater than their individual predictive efficacy(Z=4.526,4.209,P＜0.001).Conclusion The decrease of serum osteocalcin and SIRT6 in AIS patients are related to the severity and prognosis of AIS,and the combination of the two can improve the predictive value of poor prognosis.
维普
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