Relationship between serum AAT,RANTES,and Resistin levels and the condition and prognosis of patients with acute ischemic stroke with atherosclerosis of large arteries
Objective To investigate the relationship between serum alpha-1 antitrypsin(AAT),regulated upon activation normal T cell expressed and secreted(RANTES),and Resistin levels and the condition and prognosis of patients with large artery atherosclerosis(LAA)-type acute ischemic stroke(AIS).Methods One hundred and fifty-nine patients with LAA-type AIS were admitted to the Department of Neurology,Xianyang Hospital,Yan'an University,from January 2022 to January 2023,and included them in the AIS group.31 patients were divided into mild subgroups,72 cases of moder-ate subgroups,and 56 cases of severe subgroups according to the score of the National Institutes of Health Stroke Scale(NIHSS)at the time of hospitalization.In addition,84 cases of healthy volunteers who underwent physical examination in the hospital during the same period were selected to be included in the healthy control group.After 90 d of follow-up,patients with LAA-type AIS were categorized into 61 cases of poor prognosis subgroup and 98 cases of good prognosis subgroup according to the modified Rankin Scale score.Multifactorial Logistic regression was used to analyze the factors affecting the prognosis of LAA-type AIS patients,and receiver operating characteristics(ROC)curves were analyzed to predict the prog-nostic value of serum AAT,RANTES,and Resistin levels in LAA-type AIS patients.Results Compared with the healthy control group,and the serum AAT,RANTES,and Resistin levels were elevated in the AIS group(t/P= 16.897/＜0.001,20.334/＜0.001,and 17.775/＜0.001).AAT,RANTES,and Resistin levels were elevated in mild,moderate,and severe sub-groups in that order(F/P=146.195/＜0.001,192.910/＜0.001,194.396/＜0.001).At 90 d of follow-up,the incidence of poor prognosis in 159 patients with LAA-type AIS was 38.36%.Independent riskfactors affecting the prognosis of patients with LAA type AIS were increased age,diabetes mellitus,increased NIHSS score on admission,elevated AAT,elevated RAN-TES,and elevated Resistin[OR(95%CI)=1.078(1.019-1.141),2.774(1.010-7.622),1.106(1.054-1.160),1.597(1.057-2.414),1.136(1.059-1.219),1.097(1.035-1.163)];serum AAT,RANTES,Resistin levels and the areaunder the curve of the combi-nation of the three predicted poor prognosis in patients with LAA-type AIS were 0.769,0.771,0.766,and 0.897,respectively,and the area under the curve of the combination of the three was greater than that predicted alone(Z/P=3.484/0.001,3.416/0.001,3.230/0.001).Conclusion Elevated serum AAT,RANTES,and Resistin levels in LAA-type AIS patients are closely associated with exacerbation and poor prognosis,and the combination of serum AAT,RANTES,and Resistin levels is of high value in predicting the poor prognosis of LAA-type AIS patients.
Acute ischemic stroke,atherosclerotic type of large arteriesAlpha-1 antitrypsinActivated regulation of normal T-cell expression and secretion of factorsResistinPrognosis
维普
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