Objective To detect the levels of serum phosphorus oxysterase 1(PON1)and 1,25 dihydroxyvitamin D3[1,25(OH)2 D3]and their predictive value of predictive value of concomitant cardiovascular disease(CVD)in patients with psoriasis.Methods Eighty eight patients with psoriasis admitted to the Department of Dermatology,980 Hospital of the Joint Logistic Support Force of Chinese People's Liberation Army,from February 2018 to February 2022 were selected as the psoriasis group,which was subdivided into a mild subgroup according to the severity of the disease(n=34),a moderate subgroup(n=26)and severe subgroup(n=28);according to whether combined CVD was divided into non-CVD subgroup 63 cases and CVD subgroup 25 cases.Seventy cases of healthy people who underwent medical examination in the same pe-riod in the hospital were selected as the healthy control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum PON1 and 1,25(OH)2 D3 levels;differences in serum PON1 and 1,25(OH)2 D3 levels were compared among psori-asis patients with different degrees of disease;multifactorial Logistic Regression analysis of the factors affecting the compli-cation of CVD in patients with psoriasis;analysis of the predictive value of serum PON1 and 1,25(OH)2 D3 on the complica-tion of CVD in patients with psoriasis by working characteristic curve of the subjects.Results The serum PON1 and 1,25(OH)2 D3 levels in the psoriasis group were lower than those in the healthy control group(t=51.008,25.088,P＜0.001).Com-parison of serum PON1 and 1,25(OH)2 D3 levels showed that mild subgroup＞moderate subgroup＞severe subgroup(F= 207.130,54.240,P＜0.001);high Framingham risk score(FRS score)was an independent risk factor affecting patients with psoriasis complicating CVD,and elevated serum PON1 and 1,25(OH)2 D3 were protective factors[OR(95%CI)= 1.791(1.294-2.480),0.623(0.493-0.786),0.630(0.495-0.802)];serum PON1,1,25(OH)2 D3 and the combination of the two predic-ted the AUC of concurrent CVD in psoriasis patients to be 0.815,0.784,and 0.878,respectively,and the AUC of the two combinations was higher than that of serum PON1 and 1,25(OH)2 D3 diagnosed alone,and the difference was statistically significant(Z/P=3.124/0.002,3.349/0.001).Conclusion The serum PON1 and 1,25(OH)2 D3 levels in psoriasis patients are related to the severity of the disease in psoriasis patients,which is expected to be used as a new indicator to evaluate the occurrence of CVD in psoriasis patients.
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