Objective To investigate the correlation between serum lipopolysaccharide(LPS),lysyl oxidase-like 2(LOXL2)and recurrence after radiofrequency catheter ablation(RFCA)in patients with paroxysmal atrial fibrillation(PAF).Methods One hundred and ninety-seven patients with PAF who underwent RFCA in the Department of Emergency Cardi-ovascular Medicine of the People's Hospital of the Inner Mongolia Autonomous Region from May 2020 to May 2022(the PAF group)and 78 physically examined healthy people in the same time period(the control group)were selected,and were divided into the recurrent subgroup(63 patients)and the non-recurrent subgroup(134 patients)according to whether or not they had relapsed at the one-year follow up.Serum LPS and LOXL2 levels were measured by enzyme-linked immunosorbent assay.The factors of postoperative recurrence of RFCA in PAF patients were analyzed by multifactorial Logistic regression,and the predictive value of serum LPS and LOXL2 levels for postoperative recurrence of RFCA was analyzed by ROC curve.Results Serum LPS and LOXL2 levels were elevated in the PAF group compared with the control group(Z=5.575,6.903,all P<0.001).The 1-year recurrence rate of RFCA in 197 PAF patients was 31.98%(63/197).Serum LPS and LOXL2 levels were elevated in the recurrent subgroup compared with the non-recurrent subgroup(Z=6.431,6.543,all P<0.001).Prolonged dis-ease duration,increased LAD,elevated LPS,and elevated LOXL2 were independent risk factors for recurrence after RFCA in patients with PAF[OR(95%CI)=2.335(1.450-3.761),1.289(1.049-1.586),1.025(1.014-1.035),1.004(1.002-1.006)].The AUCs predicted by serum LPS,LOXL2 and the combination of the two were 0.784,0.789,and 0.859,and the AUCs of the combination of the two were greater than the AUCs predicted by serum LPS and LOXL2 levels alone(Z=2.549,3.000,P= 0.011,0.003).Conclusion Elevated serum LPS and LOXL2 levels in patients with PAF are independent risk factors for re-currence after RFCA in patients with PAF,and the combination of serum LPS and LOXL2 levels has a high predictive value for recurrence after RFCA in patients with PAF.
Paroxysmal atrial fibrillationLipopolysaccharideLysyl oxidase-like protein 2Radiofrequency catheter ablationRecurrence
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