Objective To explore the difference of erythrocyte parameters such as serumferritin,mean corpuscular volume(MCV)and mean corpuscular hemoglobin(MCH)in patients with iron deficiency anemia(IDA)and their correlation with disease severity.Methods Clinical data of 102 IDA patients treated in the Internal Medicine Department of Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region from October 2021 to March 2023 were Retrospective ana-lyzed.According to the severity of the disease,the patients were divided into mild to moderate IDA group(n=64)and se-vere IDA group(n=38).The general clinical data,iron metabolism indexes such as ferritin,serum ferritin(SF)and total iron binding capacity(TIBC),erythrocyte parameters such as mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH)and erythrocyte distribution width(RDW),reticulocyte(RET)count,RET percentage and hemoglobin content of re-ticulocyte(RET-He)were compared between the two groups.The differences of various indexes among patients with differ-ent prognosis were analyzed,and the risk factors of serious condition in IDA patients were screened by Spearman correla-tion analysis and multivariate Logistic regression analysis.Results Serum ferritin,SF,MCV,MCH,RET percentage and RET-He in severe IDA group were significantly lower than those in mild to moderate IDA group(t/P=5.091/<0.001,5.513/<0.001,3.191/0.002,5.338/<0.001,5.244/<0.001,5.745/<0.001),while serum TIBC level,RDW and RET count were signifi-cantly higher than those in mild to moderate IDA group(t/P=4.215/<0.001,5.770/<0.001,3.874/<0.001).The severity of IDA patients was positively correlated with serum TIBC,RDW and RET count,and negatively correlated with serum ferritin(r/P= 0.390/<0.001,0.496/<0.001,0.386/<0.001),SF,MCV,MCH,RET percentage and RET-He(r/P=-0.477/<0.001,-0.506/<0.001,-0.302/0.002,-0.475/<0.001,-0.466/<0.001,-0.500/<0.001).Multivariate Logistic regression analysis showed that the increase of ferritin and the level of MCH in patients with IDA were the protective factors of severe illness[OR(95%CI)= 0.780(0.631-0.965),0.556(0.328-0.941)].Conclusion There are great differences in iron metabolism,erythrocyte parameters and reticulocyte parameters in IDA patients with different severity,in which the decrease of ferritin and MCH levels may in-dicate that the condition of IDA patients is more serious.Monitoring related indicators will more accurately evaluate the condition of IDA patients and provide a certain guiding value for clinical treatment.
Iron deficiency anemiaFerritinErythrocyte parametersSeverity
国家科技期刊平台
NSTL
维普
万方数据
