Objective To investigate the effects of hyperthermic intraperitoneal chemotherapy(HIPEC)assisted with tirelizumab on immune function,tumor markers,tumor invasion-related indicators,quality of life and clinical efficacy in patients with advanced gastric cancer.Methods Eighty-six patients with advanced gastric cancer treated in the hospital from January 2022 to February 2023 were randomly divided into conventional chemotherapy group(n=43)and combination therapy group(n=43).Conventional chemotherapy group was given conventional FOLFOX chemotherapy regimen,and combination treatment group was given HIPEC chemotherapy regimen and intraperitoneal tirelizumab injection on the basis of FOLFOX chemotherapy regimen.The clinical efficacy,quality of life(KPS),expression levels of immune function(CD4+T cell ratio,CD8+T cell ratio,CD4+/CD8+ratio),tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9)]and tumor invasion-related markers[vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),matrix metalloproteinase-2(MMP-2)]were compared between the two groups before and 6 months after treatment.Results The DCR of combined chemotherapy group was 69.77％,significantly higher than that of conventional chemotherapy group(46.51％,x2/P=3.842/0.050).After6 months of treatment,the CD4+T cell ra-tio and CD4+/CD8+ratio in the combined therapy group were significantly higher than those in the conventional chemo-therapy group,while the CD8+T cell ratio was significantly lower than those in the conventional chemotherapy group(t/P=4.135/＜0.001,2.980/0.004,3.864/＜0.001).CEA and CA125 levels were significantly lower than those before treatment and in conventional chemotherapy group(t/P=5.926/＜0.001,2.961/0.004),CA19-9 level had no significant difference between the two groups(P＞0.05).The levels of VEGF,bFGF and MMP-2 decreased in both groups,and the average levels of VEGF and MMP-2 in the combined treatment group were lower than those in the conventional chemotherapy group(t/P=2513/0.014,2.390/0.019),but there was no significant difference in the level of bFGF between the two groups(P＞0.05).The average KPS score of the two groups increased successively after 3 and 6 months of treatment,and the level of KPS in the com-bined treatment group was higher than that in the conventional chemotherapy group(P＜0.05).Conclusion Compared with the traditional chemotherapy regimen,HIPEC chemotherapy combined with tirelizumab can significantly improve the immune function of patients with advanced gastric cancer and reduce the levels of tumor markers and tumor invasion-related inde-xes,which is helpful to improve the clinical efficacy and quality of life of patients.
维普
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