Objective To investigate the changes and clinical significance of serum regenerated islet-derived pro-tein 3β(Reg3β)and oncostatin M(OSM)levels in patients with acute coronary syndrome(ACS).Methods One hundred and eighty-three patients with ACS admitted to the Department of Emergency of Hainan Affiliated Hospital of Hainan Medi-cal University/Hain an General Hospital from September 2021 to December 2022 were selected as the ACS group,and sixty-five healthy people who underwent physical examination in the hospital during the same period were selected as the healthy control group,and then the patients with ACS were divided into poor prognosis subgroup(52 cases)and good prognosis subgroup(131 cases)according to prognosis.Serum Reg3β and OSM levels were detected by enzyme-linked immunosor-bent assay;Spearman correlation analysis was performed to analyze the correlation between serum Reg3β and OSM levels in patients with ACS;and factors of poor prognosis and the predictive value of serum Reg3β and OSM levels in patients with ACS were analyzed by multifactorial Logistic regression and ROC curve.Results Compared with the healthy control group,serum Reg3β and OSM levels were elevated in the ACS group(t/P=7.748/＜0.001,9.450/＜0.001).The incidence rate of 12-month poor prognosis in 183 ACS patients was 28.42％(52/183),and compared with the good prognosis subgroup,the poor prognosis subgroup had elevated serum Reg3β and OSM levels(t/P=7.390/＜0.001,7.087/＜0.001).Serum Reg3β was positively correlated with OSM levels in patients with ACS(rs/P=0.793/＜0.001).The independent risk factors for poor prog-nosis in patients with ACS were increased age,KILLIP classification ≥ grade Ⅱ,increased Gensini score and elevated Reg3β,elevated OSM[OR(95％CI)=1.071(1.008-1.138),3.709(1.186-11.600),1.045(1.022-1.067),1.014(1.007-1.021),1.007(1.004-1.010)].Serum Reg3β,OSM levels,and the combination of the two predicted the area under the curve(AUC)of poor prognosis in ACS patients were 0.784,0.789,and 0.861,respectively,and the AUC of the combination of the two was better than that for the serum Reg3β and OSM levels alone(Z/P=2.955/0.003,2.696/0.007).Conclusion Serum Reg3β and OSM levels are elevated in ACS patients and are closely associated with poor prognosis,and the combination of the two have high value in predicting poor prognosis in ACS patients.
维普
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