Effects of citicoline sodium combined with folic acid on neurocognitive function and immune inflammation in patients with ischemic stroke after thrombolytic therapy
Objective To investigate the effect of citicoline sodium combined with folic acid on neurocognitive function,stroke-related indicators,inflammation level,daily living ability and clinical safety of patients with ischemic stroke after thrombolysis.Methods Eighty-four patients with ischemic stroke after thrombolysis in Department of Neurology,the First People's Hospital of Chuzhou City from November 2021 to January 2023 were randomly divided into conventional reha-bilitation group(n=42)and combined rehabilitation group(n=42):The conventional rehabilitation group was treated with routine thrombolytic therapy and rehabilitation therapy,and the combined rehabilitation group was treated with citicoline so-dium and folic acid on the basis of conventional thrombolytic therapy.Neurocognitive function[NIHSS score,NCSE score,MMSE score],stroke-related indicators[D-dimer(D-D),homocysteine(Hcy),neuron-specific enolase(NSE)],inflammation level[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and activities of daily living[Barthel index scale,modified Rankin scale(mRS)]were compared between the two groups before and after 3 months of treatment.The incidence of adverse events during follow-up were compared between two groups.Results The NCSE and MMSE scores of patients in the combined rehabilitation group were significantly higher than those in the control group,and NIHSS scores were significantly lower than those in the control group(t/P=2275/0.026,4.371/＜0.001,6.696/＜0.001).The mean Hey and NSE levels were significantly lower than those before treatment and in the conventional rehabilitation group(t/P=8290/＜0.001,3236/0.002),and the mean D-D level was lower than that before treatment,but there was no significant difference between the two groups(P＞0.05).CRP,IL-6 and TNF-α levels were significantly lower than those before treatment and in the conventional rehabilitation group(t/P=3250/0.002,4.804/＜0.001,6.273/＜0.001).The average Barthel index was signifi-cantly higher than that before treatment and conventional rehabilitation group(t/P=2 281/0.025),and the average mRS score was lower than that before treatment,but there was no significant difference between the two groups(P＞0.05).There was no statistical difference between the incidence of adverse events in two groups(P＞0.05).Conclusion Compared with con-ventional rehabilitation therapy,citicoline sodium combined with folic acid can significantly improve the neurocognitive func-tion of patients with ischemic stroke after thrombolytic therapy,reduce stroke-related indicators and body inflammation level,and improve the daily living ability of patients while ensuring clinical safety.It has important clinical significance for the re-habilitation of stroke patients after thrombolytic therapy.
维普
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