Objective To explore the effectiveness and safety of high tibial osteotomy(HTO)combined with ar-throscopic microfracture in the treatment of knee varus osteoarthritis.Methods Sixty-three patients with knee varus osteo-arthritis admitted to Department of Orthopedics of Urumqi Friendship Hospital were prospectively selected from February 2020 to July 2021 and were divided into control group(32 cases)and study group(31 cases)according to the random enve-lope method.The control group underwent HTO combined with arthroscopic surgery,and the study group was given HTO combined with arthroscopic micro fracture,and both groups received the same postoperative rehabilitation training.The Out-erbridge grading cartilage repair at the time of initial surgery and secondary exploration,levels of inflammatory factors before and after surgery,Visual Analogue Scale(VAS)score and International Knee Documentation Committee Subjective Function(IKDC)score were compared between the two groups of patients,and the complications of the two groups were counted and compared.Results There was no significant difference in cartilage injury between the two groups at the time of initial surgery(P＞0.05).At the time of second postoperative exploration,the cartilage repair effect in study group was significant-ly better than that in control group(x2=5.980,P=0.014).The levels of tumor necrosis factor-α(TNF-α)and prostaglandin E2(PGE2)in study group at 3 days after the second surgery were significantly lower than those in control group(t=2.784,3.103,P=0.007,0.003).The VAS score in both groups at 6 months,1 year and 2 years after surgery showed a gradient over time,and the score was lower than that before surgery(P＜0.05),and the VAS scores in study group at various time points after surgery were lower than those in control group(t=2.160,2.864,2.665,P=0.035,0.006,0.010).The IKDC score in the two groups revealed a gradient at 6 months,1 year and 2 years after surgery and was higher than that before surgery(F=138229,160.509,all P＜0.001),and the IKDC scores at various time point after surgery were higher in study group than those in control group(t=2.997,3.160,2.447,P=0.004,0.003,0.017).There was no significant difference in the total inci-dence rate of complications between the two groups(P＞0.05).Conclusion HTO combined with arthroscopic microfracture can promote articular cartilage repair,relieve pain and improve knee function in patients with knee varus osteoarthritis,and it has good safety and high clinical value in cartilage recovery of knee varus osteoarthritis.
维普
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