Objective To explore the diagnostic value of transvaginal ultrasound(TVUS)combined with serum se-cretory leukocyte peptidase inhibitor(SLPI)and soluble mesothelin-related peptide(SMRP)in benign and malignant ovarian tumors.Methods From January 2022 to June 2023,120 patients with ovarian tumor diagnosed and treated in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine were selected and divided into benign group(70 cases)and malignant group(50 cases)according to the pathological diagnosis results.The patients were examined by gray-scale ultrasound and color Doppler ultrasound with color Doppler ultrasound diagnostic instrument,and the parameters were recorded.The levels of SLPI and SMRP were detected by ELISA.Multivariate Logistic regression analysis was used to ana-lyze the influencing factors of benign and malignant ovarian tumors;ROC curve analysis of TVUS combined with SLPI and SMRP in the diagnosis of benign and malignant ovarian tumors.Results In the benign group,there were 59 cases(84.3％)of benign and 11 cases(15.7％)of malignant TVUS,17 cases(34.0％)of benign and 33 cases(66.0％)of malig-nant(x2=31.759,P＜0.001).The maximum diameter of lesion,the highest systolic equivalent blood flow velocity(Vs)and the lowest diastolic peak blood flow velocity(Vd)in malignant group were higher than those in benign group(t/P=6.074/＜0.001,3 247/0.002,3.048/0.003).Compared with the benign group,the levels of SLPI and SMRP in the malignant group were higher(t=7.515,7.818,P＜0.001).High SLPI,high SMRP,high Vs and high Vd are independent risk factors for ovarian ma-lignant tumor[OR(95％CI)=1.625(1.066-2.477),1.834(1.053-3.194),1.375(1.033-1.831),1.624(1.059-2.490)].The AUC of serum TVUS,SLPI,SMRP and their combination in the diagnosis of benign and malignant ovarian tumors were 0.751,0.820,0.813 and 0.948,respectively.The AUC of the combined diagnosis of TVUS,SLPI,SMRP and their combination was better than that of their individual diagnosis(Z=5.468,3.441 and 3517,P＜0.001).Conclusion The increased expression of SLPI and SMRP in serum of patients with malignant tumor is the influencing factor of malignant tumor.TVUS combined with SLPI and SMRP has high value in diagnosing benign and malignant ovarian tumors and can be used in clinical practice.
Benign or malignant ovarian tumorsTransvaginal ultrasoundSecretory leukocyte peptidase inhibitorSoluble mesothelin-related peptideDiagnostic value
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