Objective To investigate the predictive value of serum S100 calcium binding protein All(S100A11)and allogeneic inflammatory factor 1(AIF1)in patients with high grade cervical intraepithelial neoplasia(CIN).Methods Ninety-eight CIN patients(CIN group)treated in Northwest University First Hospital from January 2021 to January 2024 were selected.During the same period,50 patients with chronic cervicitis confirmed by biopsy were selected as the disease control group,and 50 healthy women who underwent physical examinations were selected as the healthy control group.En-zyme linked immunosorbent assay was used to detect serum S100A11 and AIF1 levels in each group.Multivariate Logistic regression analysis was used to identify factors that influence the occurrence of high-grade CIN.The predictive value of se-rum S100A11 and AIF1 on the occurrence of high-grade CIN was analyzed by analyzing the receiver operating characteristic curve.Results The serum levels of S100A11 and AIF1 in the CIN group were higher than those in the healthy control group and the disease control group,and the differences were statistically significant(F/P=369.360/＜0.001,269.282/＜0.001).The serum S100A11 and AIF1 levels in CIN patients with high CIN grade Ⅱ-Ⅲ and high-risk HPV infection posi-tivity were higher than those in CIN grade Ⅰ and high-risk HPV infection negative patients,and the differences were statis-tically significant(F/P=95.082/＜0.001,92.990/＜0.001;t/P=7.903/＜0.001,5.392/＜0.001).Positive high-risk HPV infection,elevated serum S100A11,and elevated AIF1 were independent risk factors affecting the occurrence of high-grade CIN[OR(95％CI)=1278(1.149-1.420),1270(1.114-1.448),1.339(1.079-1.661)].The area under the curve of combined detec-tion of serum S100A11 and AIF1in predicting for high-grade CIN occurrence was 0.906,higher than serum S100A11,AIF1 alone 0.795,0.813,and the difference was statistically significant(Z=3.930,3.515,P＜0.001).Conclusion The serum S100A11 and AIF1 levels in CIN patients are elevated,which are related to CIN grading and high-risk HPV infection.The combination of the two has high predictive value for the occurrence of high-grade CIN.
Cervical intraepithelial neoplasiaS100 calcium binding protein A11Inflammatory factor 1 in homolo-gous transplantationForecast value
维普
万方数据
