Objective To systematically evaluate the safety and effectiveness of Taohong Siwu Decoction(TSD)in the treatment of diabetes peripheral neuropathy(DPN),so as to provide a basis for Chinese medicine intervention in DPN.Methods The PubMed database,Embase database,Cochrane Library database,CNKI,VIP,Wanfang data knowledge serv-ice platform were systematically searched,and the research literature on the treatment of diabetes peripheral neuropathy with Taohong Siwu Decoction was collected.The search time was fromthe establishment of the database to December 2023.Two researchers screened the literature,evaluated the quality,and extracted effective data.The Meta-analysis was conducted with Revman 5.4 software.Compare the clinical efficacy,median nerve conduction velocity,common peroneal nerve conduc-tion velocity,traditional Chinese medicine syndrome score,TCSS score,glycated hemoglobin level(HbA1c),and adverse re-actions between single/combined use of Taohong Siwu Decoction(experimental group)and conventional Western medicine(control group).Result The final inclusion of 13 RCTs included 1159 study subjects.The Meta-analysis showed that the experimental group had a better effect on improving clinical efficacy than the control group[RR(95％CI)=120(1.14,127),P＜0.001],the experimental group had a better effect on reducing traditional Chinese medicine syndrome scores than the control group[MD(95％CI)=-3.68(-4.64,-2.72),P＜0.001],the experimental group had a better effect on reducing TC-SS scores than the control group[MD(95％CI)=-1.77,(-2.43,-1.10),P＜0.001],and the experimental group had a bet-ter effect on improving median nerve conduction velocity than the control group[MD(95％CI)=4.07(1.98,6.15),P＜0.001].The experimental group showed a better effect on improving the conduction velocity of the common peroneal nerve than the control group,but there bad no significant statistical difference[MD(95％CI)=4.81(3.00,6.61),P＜0.001],the experi-mental group showed a better effect in reducing glycated hemoglobin levels than the control group,but there had no signifi-cant statistical difference[MD(95％CI)=-0.04(-0.28,0.19),P＜0.001].Conclusion Taohong Siwu Decoction can be used to treat diabetes peripheral neuropathy.The combination of western medicine has a significant effect,which is better than that of western medicine alone.However,it still needs to expand the sample size and collect more high-quality studies to verify.
维普
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