Studies have shown that hypertension is closely related to the changes of gastrointestinal microbiome.Host-microbial-microbial metabolites interact and influence with each other.These changes may lead to the activation of sig-nal pathways and eventually affect the pathophysiology of cardiovascular diseases.These molecules may become targets for therapeutic applications.The purpose of this paper is to explore the relationship between gastrointestinal microbiome and blood pressure,and to summarize the current strategies for regulating the disorder of intestinal microflora based on the mechanism of intestinal microflora affecting blood pressure,so as to provide new ideas and vision for the development of antihypertensive drug targets.