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肠道菌群与高血压关系的研究进展

Research progress on the relationship between gastrointestinal microbiome and hypertension

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高血压与肠道菌群的变化密切相关,宿主—微生物—微生物代谢产物之间相互作用、相互影响,这些改变可能会导致信号通路的激活,最终对心血管疾病的病理生理产生影响,这些分子都可能成为治疗应用的靶点.文章旨在探讨肠道微生物与血压之间的相互关系,以肠道菌群影响血压的机制为切入点,总结目前调节肠道菌群紊乱的策略,为降压药物靶点的开发提供新的思路和视野.
Studies have shown that hypertension is closely related to the changes of gastrointestinal microbiome.Host-microbial-microbial metabolites interact and influence with each other.These changes may lead to the activation of sig-nal pathways and eventually affect the pathophysiology of cardiovascular diseases.These molecules may become targets for therapeutic applications.The purpose of this paper is to explore the relationship between gastrointestinal microbiome and blood pressure,and to summarize the current strategies for regulating the disorder of intestinal microflora based on the mechanism of intestinal microflora affecting blood pressure,so as to provide new ideas and vision for the development of antihypertensive drug targets.

HypertensionGastrointestinal microbiomeProbioticShort-chain fatty acids

孙鹏伟、皇甫卫忠

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010030 呼和浩特,内蒙古医科大学/内蒙古医科大学附属医院全科医学/内蒙古自治区心血管研究所

高血压 肠道菌群 益生菌 短链脂肪酸

内蒙古自治区关键技术攻关项目内蒙古自治区卫生健康委科技项目内蒙古医科大学附属医院院级项目-科研联合基金内蒙古自治区神经系统疾病临床医学研究中心项目首府地区高质量发展优势临床重点专科神经系统疾病项目

2021GG01732022012612023NYFY LHYB009

2024

疑难病杂志
中国医师协会

疑难病杂志

CSTPCD
影响因子:1.171
ISSN:1671-6450
年,卷(期):2024.23(6)