Oxidative stress(OS)denotes the physiological and pathological response resulting from an imbalance between oxidation and antioxidation under the deleterious influence of internal and external stimuli.This imbalance leads to the accumulation of active oxygen free radicals and active nitrogen free radicals.OS serves as a crucial mechanism contribu-ting to various acute and chronic diseases,as well as the aging process.As the visual organ of the human body,eyeball is consistently exposed to the external environment and undergoes robust metabolism,its structure is particularly susceptible to OS-induced damage,consequently giving rise to eye diseases.Therefore,this paper provides a comprehensive review of oxidative stress factors and their mechanisms in age-related eye diseases,elucidating the OS mechanisms prevalent in major senile eye diseases.
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