Objective To compare the therapeutic effects of lansoprazole and rabeprazole on postoperative reflux esophagitis in patients with esophageal cancer.Methods Two hundred and two patients with postoperative reflux esoph-agitis diagnosed in our hospital from August 2019 to October 2023 were randomly divided into experimental group(n=101)and control group(n=101).The control group was given routine support therapy and rabeprazole sodium enteric-coated capsule oral treatment,while the experimental group was given routine support therapy and lansoprazole capsule oral treat-ment.The therapeutic effects and adverse drug reactions were compared between the two groups after 4 weeks of treatment,and the levels of digestive function related indexes(Gas,MTL,CGRP)and serum inflammation related indexes(IL-4,IL-6,IL-17,IL-23)were compared between the two groups.Results There was no significant difference in the total effective rate between the test group and the control group(P＞0.05).After 4 weeks of treatment,the levels of Gas and MTL in the test group were higher than patients in the control group,while CGRP was signicantly lower than patients in the control group(t/P=9.550/＜0.001,7.735/＜0.001,12.398/＜0.001).The serum levels of IL-6,IL-17 and IL-23 in the test group were signifi-cantly lower than patients in the control group,while IL-4 was higher(t/P=13.039/＜0.001,22.533/＜0.001,7.635/＜0.001,7.682/＜0.001).There was no significant difference in the incidence of total adverse reactions between the two groups(P＞0.05).Conclusion Both lansoprazole and rabeprazole can significantly relieve the symptoms of postoperative reflux esoph-agitis in patients with esophageal cancer,in which lansoprazole can better improve the digestive function,reduce the level of inflammation,which has a broader prospect of clinical application.
Postoperative reflux esophagitis of esophageal cancerLansoprazoleRabeprazoleTherapeutic effect
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