兰索拉唑与雷贝拉唑治疗食管癌术后反流性食管炎的疗效比较
Comparison of lansoprazole and rabeprazole in the treatment of reflux esophagitis after operation of esophageal carci-noma
刘文 1罗继文 1杨艳刚 1任杰1
作者信息
- 1. 621000 四川省绵阳市中心医院心胸外科
- 折叠
摘要
目的 比较兰索拉唑与雷贝拉唑对食管癌术后反流性食管炎患者的治疗效果.方法 收集2019年8月-2023年10月绵阳市中心医院心胸外科诊治食管癌术后反流性食管炎患者202例,按照随机数字表法分为研究组101例和对照组101例.对照组术后常规支持治疗及雷贝拉唑钠肠溶胶囊口服,研究组常规支持治疗及兰索拉唑胶囊口服.比较2组患者术后、治疗4周后消化功能相关指标(Gas、MTL、CGRP)及血清炎性相关指标(IL-4、IL-6、IL-17、IL-23)水平变化及药物不良反应,并比较治疗4周后的临床疗效.结果 治疗4周后2组总有效率比较差异无统计学意义(P＞0.05);治疗4周后,研究组Gas及MTL均高于对照组,CGRP低于对照组(t/P=9.550/＜0.001,7.735/＜0.001,12.398/＜0.001);血清 IL-6、IL-17 及 IL-23 水平均低于对照组,IL-4 高于对照组(t/P=13.039/＜0.001,22.533/＜0.001,7.635/＜0.001,7.682/＜0.001).2组患者治疗过程中总不良反应发生率比较差异无统计学意义(P＞0.05).结论 兰索拉唑及雷贝拉唑均能显著缓解食管癌术后反流性食管炎患者的症状,其中兰索拉唑能更好地改善患者消化功能、降低炎性反应水平,具有更广阔的临床应用前景.
Abstract
Objective To compare the therapeutic effects of lansoprazole and rabeprazole on postoperative reflux esophagitis in patients with esophageal cancer.Methods Two hundred and two patients with postoperative reflux esoph-agitis diagnosed in our hospital from August 2019 to October 2023 were randomly divided into experimental group(n=101)and control group(n=101).The control group was given routine support therapy and rabeprazole sodium enteric-coated capsule oral treatment,while the experimental group was given routine support therapy and lansoprazole capsule oral treat-ment.The therapeutic effects and adverse drug reactions were compared between the two groups after 4 weeks of treatment,and the levels of digestive function related indexes(Gas,MTL,CGRP)and serum inflammation related indexes(IL-4,IL-6,IL-17,IL-23)were compared between the two groups.Results There was no significant difference in the total effective rate between the test group and the control group(P＞0.05).After 4 weeks of treatment,the levels of Gas and MTL in the test group were higher than patients in the control group,while CGRP was signicantly lower than patients in the control group(t/P=9.550/＜0.001,7.735/＜0.001,12.398/＜0.001).The serum levels of IL-6,IL-17 and IL-23 in the test group were signifi-cantly lower than patients in the control group,while IL-4 was higher(t/P=13.039/＜0.001,22.533/＜0.001,7.635/＜0.001,7.682/＜0.001).There was no significant difference in the incidence of total adverse reactions between the two groups(P＞0.05).Conclusion Both lansoprazole and rabeprazole can significantly relieve the symptoms of postoperative reflux esoph-agitis in patients with esophageal cancer,in which lansoprazole can better improve the digestive function,reduce the level of inflammation,which has a broader prospect of clinical application.
关键词
食管癌术后反流性食管炎/兰索拉唑/雷贝拉唑/疗效Key words
Postoperative reflux esophagitis of esophageal cancer/Lansoprazole/Rabeprazole/Therapeutic effect引用本文复制引用
基金项目
四川省卫生健康委科研课题(19PJ047)
出版年
2024
国家科技期刊平台
NSTL
万方数据