Objective To investigate the expression of soluble interleukin-2 receptor(sIL-2R)and Eotaxin-1 in the serum of gastric cancer patients and their correlation with Helicobacter pylori(Hp)infection.Methods One hundred and eighteen gastric cancer patients admitted to the Department of Gastroenterology at Beidahuang Group General Hospital from July 2021 to August 2023 were selected as the study group,and 107 patients with benign gastric lesions during the same period were selected as the control group.ELISA was applied to detect the expression levels of serum sIL-2R and Eotaxin-1;Hp detector was applied to detect Hp infection;Spearman method was applied to analyze the correlation between serum sIL-2R,Eotaxin-1 expression levels and Hp infection in patients.Results The expression levels of serum sIL-2R and Eotax-in-1 in the study group were higher than those in the control group(t=8.417,7.287,P＜0.001);The levels of sIL-2R and Eotaxin-1 in the serum of patients with low differentiation,lymph node metastasis,and TNM stage Ⅲ+Ⅳ were higher than those in patients with medium/high differentiation,no lymph node metastasis,and TNM stage Ⅰ+Ⅱ(t=2.966,3.164,2.631,P=0.004,0.002,0.010)(t=2232,2509,2.613,P=0.028,0.013,0.010);the positive rate of Hp in the study group was higher than that in the control group(x2=16.069,P＜0.001);the expression levels of serum sIL-2R and Eotaxin-1 in patients with Hp infection were higher than those in Hp negative patients(t=2.111,5.994,P=0.037,＜0.001);Hp infection was positively correlated with serum sIL-2R and Eotaxin-1 expression levels(r=0.405,0.515,P＜0.001).Conclusion The expression levels of sIL-2R and Eotaxin-1 in serum are elevated in gastric cancer patients,and there is a correlation between the two and Hp infection.
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