Objective To investigate the effect of neoadjuvant chemotherapy(NACT)by arterial and intravenous route on chemotherapy in patients with locally advanced cervical cancer.Methods The clinical data of 178 patients with cervical cancer Ⅰ B2/Ⅱ A2(FIGO2009)who were received NACT combined with radical cervical cancer(RH)treatment and admitted to seven first-class hospitals from January 1,2009 to December 31,2016 were collected from the Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Peking University People's Hospital,Peking University First Hospital,Peking University Third Hospital,Beijing Chaoyang Hospital,Beijing Anzhen Hospital and Beijing Shijitan Hospital.The pa-tients were divided into arterial group(104 cases)and intravenous administration group(74 cases)according to different chemotherapy regimences.To compare the difference of pathological high-risk factors and clinical outcomes between the two groups,and the difference of bone marrow suppression degree after chemotherapy.Results There was no significant differ-ence in the total effective rate between the arterial group and the intravenous administration group(P＞0.05),while the lym-phatic metastasis rate in arterial administration group was lower than that of the intravenous administration group(x2/P=6.311/0.010).The hemoglobin in arterial administration group was lower than that of the intravenous administration group,and the degree of bone marrow suppression in the arterial administration group was lower than that in the intravenous adminis-tration group(t/x2=2.864,2299,P=0.005,0.022).The rate postoperative radiotherapy in arterial administration group was lower than that in intravenous administration group(x2=8.029,P=0.003).Conclusion In patients with locally advanced cervical cancer,arterial chemotherapy has potential advantages in reducing postoperative pathological risk factors and the rate of postoperative supplementary radiotherapy.
Locally advanced cervical cancerNeoadjuvant chemotherapyRoute of administrationConcurrent chemoradiotherapy
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