Relationship between serum CXCL1,CXCL16 and liver failure stage and short-term prognosis in patients with hepa-titis B virus-acute-on-chronic liver failure
Objective To investigate the relationship between serum C-X-C motif chemokine ligand(CXCL)1,CX-CL16 and liver failure stage and short-term prognosis in patients with hepatitis B virus-acute-on-chronic liver failure(HBV-ACLF).Methods A total of 170 HBV-ACLF patients admitted to the Hepatology Department of Dazhou Central Hospital from January 2018 to June 2023 were included in the study group.According to the stages of liver failure,HBV-ACLF pa-tients were divided into early subgroup(71 cases),middle subgroup(54 cases)and late subgroup(45 cases).According to the 90-day prognosis,the patients were divided into death subgroup(60 cases)and survival subgroup(110 cases),and an-other 100 healthy subjects were selected to be included in the control group.Serum CXCL1 and CXCL16 levels were detec-ted by enzyme-linked immunosorbent assay.The influencing factors of death in HBV-ACLF patients were analyzed by uni-variate and multivariate Logistic regression.The predictive effect of serum CXCL1,CXCL16,and model of end-stage liver disease(MELD)scores in HBV-ACLF patients was evaluated by receiver operating characteristic(ROC)curves.Results Compared with the control group,the serum CXCL1 and CXCL16 levels in the study group were significantly increased(t/P=30.816,＜0.001,29.811,＜0.001).Serum CXCL1 and CXCL16 levels in early subgroup,middle subgroup and late sub-group were increased successively(F/P=317.656,＜0.001,211.391,＜0.001).Compared with the survival subgroup,the ser-um CXCL1 and CXCL16 levels in the death subgroup were significantly increased(t/P=7.775,＜0.001,7.137,＜0.001).Ad-vanced stages of liver failure[OR(95％CI)=5.069(1.322-19.441)],MELD score[OR(95％CI)=1.548(1.174-2.042)],CXCL1[OR(95％CI)=1.914(1.162-3.153)],CXCL16[OR(95％CI)=3.423(1.468-7.980)]elevation were independent risk factors for death in patients with HBV-ACLF.The area under the curve of serum CXCL1 and CXCL16 combined with MELD score predicted the death of HBV-ACLF patients was 0.927,which was larger than 0.786,0.781 and 0.784 predicted by serum CXCL1,CXCL16 and MELD score alone(Z=4.594,4.261,4.288,all P＜0.001).Conclusion The levels of serum CX-CL1 and CXCL16 in HBV-ACLF patients are increase,which are relate to liver failure stage and short-term poor prognosis,the combination of serum CXCL1 and CXCL16 on the basis of MELD score has a high value in predicting the short-term prognosis of HBV-ACLF patients.
Hepatitis B virus-acute-on-chronic liver failureC-X-C motif chemokine ligandLiver failure stagePrognosis
国家科技期刊平台
NSTL
万方数据
