Objective To explore the effects of glutathione combined with sildenafil on vascular endothelial func-tion,inflammatory response level,erectile function and clinical efficacy in patients with erectile dysfunction(ED).Methods Eighty-nine ED patients diagnosed and treated in the Urology Center of the People's Hospital of Xinjiang Uygur Autono-mous Region from October 2022 to October 2023 were selected as the study objects,and were randomly divided into mono-therapy group and combined treatment group,with 44 cases in the monotherapy group and 45 cases in the combined treat-ment group.The monotherapy group was given oral sildenafil treatment,and the combined treatment group was given oral treatment with reduced glutathione tablets.All patients were treated continuously for 1 month.The clinical efficacy,vascular endothelial function(NO,ET,VEGF,ES),inflammatory response level(hs-CRP,IL-6,IL-8,IL-10),erectile function(IIEF-5,QEQ,EHS,PSV)and incidence of adverse events were compared between the two groups before treatment,at the end of treatment and one month after treatment.Results One month after the end of treatment,the total effective rate of combined treatment group was 91.11％,which was higher than that of monotherapy group(75.00％,x2/P=4.121/0.042).At the end of treatment and 1 month after treatment,the mean serum levels of NO and VEGF in combined treatment group were signifi-cantly higher than those before treatment and monotherapy group,and the mean ET levels were significantly lower than those before treatment and monotherapy group(t/P=5.323/＜0.001,3.683/＜0.001,3.808/＜0.001,2.615/0.011,3.089/0.003,3.197/0.002).Average serum hs-CRP and IL-6 levels were significantly lower than those before treatment and in monotherapy group(t/P=8.323/＜0.001,2.364/0.020,6.787/＜0.001,2.662/0.009).Average IIEF-5,QEQ,EHS and PSV were significantly higher than before treatment,and EHS and PSV were also significantly higher than monotherapy group(t/P=6.410/＜0.001,4.066/＜0.001,8.928/＜0.001,4.532/＜0.001).There was no significant difference in cure rate and incidence of adverse events between the two groups(P＞0.05).Conclusion Glutathione combined with sildenafil can effectively improve vascular en-dothelial function and erectile function in ED patients,and significantly reduce the level of inflammation.The combine treat-ment scheme has remarkable clinical efficacy and safety for ED patients,and has wide clinical application prospect.
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