外泌体检测在同种器官移植排斥反应中的应用进展
Progress in the application of exosome detection in rejection after allogeneic organ transplantation
王祎涵 1雷子龙 1高煜 1林森豪 1贾钰1
作者信息
- 1. 430030 武汉,华中科技大学同济医学院附属同济医院肾内科
- 折叠
摘要
实体器官移植是终末期器官衰竭最有效的治疗方法,然而移植后排斥反应会对移植器官造成损伤,减少移植物存活时间.近年来,液体活检成为一种检测和诊断排斥反应的重要手段,其中外泌体的研究尤其受到关注.外泌体作为生物标志物,具有非侵入性、诊断准确性高等优点,可用于诊断移植排斥反应.文章就外泌体检测在同种器官(包括肾、肺、心脏、肝脏等)移植排斥反应中的研究进展进行综述.
Abstract
Solid organ transplantation is the most effective treatment for end-stage organ failure.However,post-transplant rejection can damage the transplanted organ and reduce the survival time of the transplant.In recent years,liquid biopsy has become an important means for detecting and diagnosing rejection reactions,with particular attention paid to the study of exosomes.As biomarkers,exosomes have the advantages of being non-invasive and highly accurate in diagnosis,and can be used to diagnose transplant rejection.This article reviews the research progress of exosome detection in alloge-neic organ transplant rejection,including kidneys,lungs,hearts,livers,etc.
关键词
外泌体/器官移植/排斥反应/液体活检Key words
Exosomes/Organ transplantation/Rejection/Liquid biopsy引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(81801587)
出版年
2024
国家科技期刊平台
NSTL
万方数据