摘要
肿瘤糖酵解代谢途径是近年来肿瘤机制和诊治研究的新热点.妇科恶性肿瘤的发病率和病死率较高,严重危害女性健康和生活质量.糖酵解能力增强与妇科肿瘤的生物学行为、放化疗、治疗耐受、恶性进展和不良预后密切相关.文章就糖酵解代谢在妇科主要恶性肿瘤中的研究进展进行综述,为妇科恶性肿瘤的机制探索、诊治研究和预后评估提供新的思路.
Abstract
Abnormal glycolysis is a prominent feature of tumor cells,independent of oxygen availability.The meta-bolic pathway of tumor glycolysis has emerged as a significant focus in recent research on tumor mechanisms,diagnostics,and therapeutics.Gynecological malignancies exhibit high incidence and mortality rates,posing a significant threat to women's health and well-being.The heightened glycolytic capacity of these tumors is intricately linked to their biological be-havior,response to radiotherapy and chemotherapy,treatment tolerance,malignant progression,and overall prognosis.Sum-marize the advancements in glycolysis metabolism research within major gynecological malignant tumors,offering novel in-sights for investigating mechanisms,diagnosing and treating these tumors,as well as evaluating prognosis.
基金项目
陕西省博士后科研项目(2023BSHGZZHQYXMZZ35)
国家科技期刊平台
NSTL
万方数据