Objective To investigate the relationship between serum C-X-C motif chemokine receptor 7(CXCR7),serum/glucocorticoid-regulated kinase 1(SGK1)levels and poor prognosis after acute myocardial infarction(AMI)percuta-neous coronary intervention(PCI).Methods One hundred AMI patients who underwent PCI in the Emergency Department of the Second Affiliated Hospital of Nanjing Medical University from September 2020 to December 2022 were selected as the AMI group and 50 healthy medical check-ups in the hospital during the same period as the healthy control group,and the AMI patients were classified into 30 cases in the poor-prognosis subgroup and 70 cases in the good-prognosis subgroup according to the prognosis at 1 year after PCI.Serum CXCR7 and SGK1 levels were detected by enzyme-linked immunosor-bent assay;multifactorial logistic regression was used to analyze the influencing factors of poor prognosis after PCI in pa-tients with AMI;and a receiver operating characteristic(ROC)curve was established to evaluate the predictive value of ser-um CXCR7 and SGK1 levels for poor prognosis after PCI in patients with AMI.Results Compared with the healthy control group,serum CXCR7 levels were decreased and SGK1 levels were increased in the AMI group(t/P=9.613/＜0.001,9.955/＜0.001);the incidence rate of poor prognosis at 1 year after PCI in 100 patients with AMI was 30.00％(30/100);and compared with the subgroup with a good prognosis,the subgroup with a poor prognosis had a decreased serum CXCR7 levels were decreased and SGK1 levels were increased(t/P=6.254/＜0.001,5.329/＜0.001).Multifactorial logistic regression showed that high Gensini score,KILLIP classification ≥ grade Ⅲ,and elevated SGK1 were independent risk factors for poor prognosis after PCI in patients with AMI[OR(95％CI)=1.071(1.025-1.119),4.501(1.172-17.282),1.132(1.046-1224)],and elevated CXCR7 was an independent protective factor[OR(95％CI)=0.956(0.926-0.987)].The AUCs of ser-um CXCR7,SGK1,and the combination of the two for predicting poor prognosis of PCI in patients with AMI were 0.794,0.779,and 0.902,respectively,and the AUCs of the combination of the two were greater than those predicted by the serum CXCR7 and SGK1 levels alone(Z/P=3.062/0.002,2.930/0.003).Conclusion Reduced serum CXCR7 levels and increased SGK1 levels in AMI patients are independently associated with their poor prognosis after PCI,and the combination of the two has a high predictive value for them.
维普
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