Objective The purpose of this study is to investigate the predictive value of serum surfactant protein D(SPD)and mannose levels in patients with acute respiratory distress syndrome(ARDS)in terms of prognosis.Methods A retrospective collection was conducted on 112 ARDS patients(ARDS group)who received treatment in Respiratory and Critical Care Medicine Department of Shanxi Norman Bethune Hospital(Shanxi Academy of Medical Sciences)from February 2020 to March 2022.According to the severity of the ARDS patients,they were divided into mild subgroup(n=42),moder-ate subgroup(n=38),and severe subgroup(n=32),as well as survival subgroup(n=81)and death subgroup(n=31)based on the prognosis.60 healthy individuals were taken as the healthy control group.Enzyme-linked immunosorbent as-say was used to detect serum SPD and mannose levels.The prognostic factors of ARDS patients and the prognostic evalu-ation value of serum SPD and mannose were analyzed using statistical analysis.Results The serum SPD and mannose lev-els in the ARDS group were(16221±21.78)μg/L and(130.65±19.90)ng/L,respectively,lower than those in the healthy control group(25234±45.70)μg/L and(227.14±3721)ng/L(t=26.641,22.185,P＜0.001).The serum levels of SPD and mannose in the mild,moderate,and severe subgroups decreased significantly in sequence(F/P=142.650/＜0.001,84.621/＜0.001).Compared with the healthy control group,the SOFA score and APACHE Ⅱ score of ARDS patients in the death group were higher,while serum SPD and mannose were lower(t/P=4.366/＜0.001,6.470/＜0.001,6.099/＜0.001,8.586/＜0.001).SOFA score and APACHE Ⅱ score were risk factors affecting the 28 day mortality prognosis of ARDS patients,while serum SPD and mannose were protective factors[OR(95％CI)=1.423(1.088-1.862),1.511(1.140-2.004),0.564(0.445-0.715),0.618(0.474-0.807)].The area under the curve(AUC)for predicting the 28 day mortality prognosis of ARDS patients with serum SPD and mannose combination was 0.949,which was greater than single indicator detection of 0.826 and 0.895(Z=5.021,4.432,P＜0.001,0.002).Conclusion The serum levels of SPD and mannose in ARDS patients de-crease,which are correlated with the severity of the patient's condition.The combination of serum SPD and mannose has good predictive value for the prognosis of ARDS patients.
Acute respiratory distress syndromeSurfactant protein DMannosePrognosisPredictive value
维普
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