Objective To analyze the relationship between serum neurotensin related peptide(Xenin-25),comple-ment C1 tumor necrosis factor related protein 12(CTRP12)and pregnancy outcome in patients with gestational diabetes melli-tus(GDM).Methods Ninety-two GDM patients diagnosed and treated in the Reproductive Medicine Department of the Affiliated Hospital of North Sichuan Medical College from February 2021 to February 2022 were selected as the GDM group.According to the presence or absence of adverse pregnancy outcomes,they were divided into poor prognosis subgroup(n=34)and good prognosis subgroup(n=58).A total of 50 healthy pregnant women in the same period were enrolled as the normal pregnancy group.Serum Xenin-25 and CTRP12 were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum Xenin-25,CTRP12 and glucose metabolism indexes.Multivariate Logistic regression was used to analyze the factors affecting adverse pregnancy outcomes in GBM patients.Receiver operating characteristic curve was used to evaluate the predictive value of serum Xenin-25 and CTRP12 for preg-nancy outcome.Results The levels of serum Xenin-25 and CTRP12 in the GDM group were lower than those in the con-trol group,while the levels of fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS)and homeostasis model assessment of insulin resistance(HOMA-IR)were higher than those in the control group(t/P=16.046/＜0.001,22.114/＜0.001,11510/＜0.001,13.666/＜0.001,12.101/＜0.001,14.413/＜0.001).Serum Xenin-25 and CTRP12 levels were negatively correlated with FPG,HbA1c,FINS and HOMA-IR in GDM group(Xenin-25:r/P=-0.665/＜0.001,-0.598/＜0.001,-0.567/＜0.001,-0.702/＜0.001;CTRP12:r/P=-0.579/＜0.001,-0.622/＜0.001,-0.667/＜0.001,-0.725/＜0.001);Compared with the good prognosis subgroup,the poor prognosis subgroup had lower serum CTRP12 and Xenin-25 and higher HOMA-IR(t/P=6.783/＜0.001,17.997/＜0.001,15.146/＜0.001).High serum CTRP12 and Xenin-25 were independent protective factors for adverse pregnancy outcomes in GDM patients[OR(95％CI)=0.646(0.499-0.837),0.619(0.465-0.824)],and high HOMA-IR was risk factor[OR(95％CI)=1.353(1.110-1.649)].The AUC of serum Xenin-25,CTRP12 and their combination for predicting adverse pregnancy outcomes in GDM patients were 0.828,0.815 and 0.870,respectively.The combination of xenin-25 and CTRP12 was superior to their individual prediction efficacy(Z/P=4.113/0.003,4327/0.001).Conclu-sion GDM patients have decreased serum CTRP12 and Xenin-25 levels,which are involved in the disease process of GDM.The combination of CTRP12 and Xenin-25 has a high evaluation value for adverse pregnancy outcomes in GDM patients.
关键词
妊娠期糖尿病/Xenin-25/C1q肿瘤坏死因子相关蛋白12/妊娠结局
Key words
Gestational diabetes/Xenin-25/Complement C1 tumor necrosis factor related protein 12/Pregnancy outcome
维普
万方数据