Objective To investigate the expression of serum growth differentiation factor-15(GDF-15)and angio-poietin-like protein 8(ANGPTL8)in the mother with fetal congenital heart disease(CHD),and the value of them combined in the diagnosis of fetal CHD.Methods A total of 120 pregnant women suspected of fetal CHD who underwent prenatal screening in our hospital from January 2020 to March 2023 were collected as research subjects.They were separated into CHD group(n=86)and non-CHD group(n=34)based on the results of Color Doppler echocardiography.The expression levels of serum GDF-15 and ANGPTL8 were compared between the two groups;Multivariate Logistic regression was used to analyze the influencing factors of fetal CHD;ROC curve was applied to analyze the diagnostic efficacy of serum GDF-15 and ANGPTL8 in fetal CHD.Results Compared with the non CHD group,the serum levels of GDF-15 and ANGPTL8 in the CHD group were obviously increased(t/P=7.860/＜0.001,7.334/＜0.001).Multivariate Logistic regression analysis showed that gravidity,family history of CHD,GDF-15 and ANGPTL8 were the influencing factors of fetal CHD[OR(95％CI)=1.383(1.082-1.767),1.596(1.148-2.218),3.596(1.694-7.633),3.175(1.571-6.417)].The AUC of serum GDF-15,ANGPTL8 and their combination in the diagnosis of fetal CHD was 0.805,0.835 and 0.903,the combination of serum GDF-15 and AN-GPTL8 in the diagnosis of fetal CHD was better than GDF-15.ANGPTL8 was independently predicted(Z=2.052,2.219,P=0.040,0.027).Conclusion The maternal serum GDF-15 and ANGPTL8 levels in fetal CHD are obviously elevated.Color Doppler echocardiography combined with maternal serum GDF-15 and ANGPTL8 has high diagnostic potential for fetal CHD.
Fetal congenital heart diseaseGrowth differentiation factor-15Angiopoietin-like protein 8Prenatal di-agnosis
维普
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