Objective To investigate the expression levels of allograft inflammatory factor-1(AIF-1),B-cell specific moloney leukemia virus insertion site 1(Bmi-1),and mannose-binding lectin associated protein 19(MAP19)in serum,and their combined diagnostic value in cervical cancer patients.Methods A total of 180 cervical cancer patients admitted from January 2023 to December 2023 were regarded as the observation group,and another 180 healthy volunteers who underwent physical examinations during the same period were selected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of AIF-1,Bmi-1,and MAP19 in the serum of two groups.The expres-sion levels of AIF-1,Bmi-1 and MAP19 in different stages of cervical cancer were compared.Spearman was applied to ana-lyze the relationship between the expression levels of AIF-1,Bmi-1,MAP19 in serum with the incidence of cervical cancer.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of serum AIF-1,Bmi-1,and MAP19 expression levels for cervical cancer.Results Compared with the control group,the expression levels of serum AIF-1,Bmi-1,and MAP19 in the observation group were increased(t=13.054,13.598,10.601,P＜0.001);The expression lev-els of AIF-1,Bmi-1 and MAP19 in serum of patients with cervical cancer increased with the increase of stage(F=32.001,8232,10.602,P＜0.001).the proportion of high expression levels of serum AIF-1,Bmi-1,and MAP19 in cervical cancer pa-tients increased in pathological low differentiation,HPV positivity,FIGO stages Ⅲ-Ⅳ,and lymph node metastasis,while the proportion of low expression levels increased in pathological moderate to high differentiation,HPV negativity,FIGO stagesⅠ-Ⅱ,and no lymph node metastasis(AIF-1:x2=41.162,27.607,13.718,23.824,P＜0.001,Bmi-1:x2=33.563,22.060,22.599,18.451,P＜0.001,MAP19:X2=49.585,14.913,25.545,13.605,P＜0.001);The AUC for predicting cervical cancer lesions by ser-um AIF-1,Bmi-1,MAP19 expression levels,and their combination were 0.759,0.726,0.751,and 0.839,respectively,with the combination being better than each individual prediction(Z=2.499,3.363,2.749,P=0.012,＜0.001,0.016).Conclusion The expression levels of AIF-1,Bmi-1,and MAP19 in the serum of cervical cancer patients are obviously increased,the expres-sion levels of AIF-1,Bmi-1 and MAP19 in serum increased with the increase of cervical cancer stage,and the combination of the three has high diagnostic efficacy for cervical cancer.
Cervical cancerAllograft inflammatory factor-1B-cell specific moloney leukemia virus insertion site 1Mannose-binding lectin associated protein 19Diagnosis
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