Objective To explore and analyze the relationship between serum levels of glucose-6-phosphate dehy-drogenase(G6PD)and insulin-like growth factor-1(IGF-1)with the severity of disease and hearing loss in neonates with hy-perbilirubinemia.Methods Clinical data of 102 newborns with high bilirubin admitted to Department of Pediatric Medicine,Xinzhou District People's Hospital from December 2022 to December 2023 were collected and assigned into mild group(n=41),moderate group(n=33),and severe group(n=28)based on the severity of their condition.Serum G6PD and IGF-1 lev-els were detected using ELISA,the general clinical data of the children were collected,receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of G6PD and IGF-1 in assessing the degree of hearing loss of the patient's condition,Logistic was applied to analyze the factors influencing the degree of hearing loss in children,Pearson method was applied to analyze the correlation between serum G6PD,IGF-1 levels,bilirubin level,and hearing thresholds in children.Results The levels of G6PD and IGF-1 in the moderate and severe groups were obviously lower than those in the mild group(F/P=51.881/＜0.001,42334/＜0.001);the serum G6PD and IGF-1 levels of children in the moderate and severe sub-groups were obviously lower than those in the mild subgroup(F/P=26.243/＜0.001,22.454/＜0.001),G6PD and IGF-1 were negatively correlated with bilirubin level and hearing thresholds in children(G6PD:r/P=-0.421/＜0.001,-0.405/＜0.001,IGF-1:r/P=-0.437/＜0.001,-0.422/＜0.001);the AUC of serum G6PD,IGF-1,and their combination in the diagnosis of the degree of hearing loss of disease was 0.780,0.800,and 0.884,respectively,the combined diagnosis was obviously better than the in-dividual diagnosis of G6PD and IGF-1(Z=2.905,2.109,P=0.004,0.035);Bilirubin and UCB were independent risk factors for the degree of hearing impairment in children[OR(95％CI)=1.354(1.111-1.650),1.157(1.022-1309)],and G6PD and IGF-1 were independent protective factors for the degree of hearing impairment in children[OR(95％CI)=0.864(0.773-0.966),0.864(0.773-0.966)].Conclusion In newborns with hyperbilirubinemia,serum levels of G6PD and IGF-1 obviously de-crease with the degree of hearing loss of disease,and both have auxiliary diagnostic value for the severity of disease,which are influencing factors for the degree of hearing loss in children.
HyperbilirubinemiaGlucose-6-phosphate dehydrogenaseInsulin-like growth factor-1Degree of ill-nessHearing lossNewborn
维普
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