Sepsis is a common and critical disease in clinical practice,which often leads to multi-organ dysfunction and even life-threatening in severe cases.As one of the most commonly affected target organs of sepsis,sepsis-associated acute kidney injury(SAKI)has a more serious impact on the prognosis of patients.The pathogenesis of SAKI is very com-plex,involving immune inflammatory response,oxidative stress,apoptosis,endothelial cell dysfunction,hemodynamic abnor-malities,mitochondrial quality control disorders and other aspects,so the pathogenesis of SAKI has not been fully elucida-ted.This article discusses the research progress on the pathogenesis of SAKI and briefly reviews it,in order to find new targets for the effective treatment of SAKI.
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