Gastric cancer,as one of the common upper gastrointestinal malignancies,often misses the optimal treat-ment window as patients tend to progress to advanced local stages or systemic metastasis at the time of initial diagnosis due to a lack of specific symptoms in the early stage.During the occurrence and development of gastric cancer,the tumor acts not only as an uncontrollable cell proliferation disease but also as a disorder resulting from a disturbed microenviron-ment.A series of studies have revealed that the tumor microenvironment plays a significant role in the initiation,progres-sion,and metastasis of the tumor.This article provides a review of the recent research advancements in the interaction mechanisms between gastric cancer cells and the tumor microenvironment signaling.
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