Objective To investigate the expression and clinical significance of serum family with sequence similar-ity 19 member 5(FAM19A5)and interleukin 34(IL-34)in patients with vascular cognitive impairment(VCI).Methods One hundred and twenty-five non-demented vascular cognitive impairment in non-dementia(VCIND)patients admitted to the Department of Neurology of Baotou Central Hospital(VCIND group)and 58 physically examined healthy people in the same time period(control group)were selected from January 2020 to December 2022,and the patients in the VCIND group were classified into the VaD subgroup(45 cases)and the non-VaD subgroup(80 cases)according to whether they progressed to vascular dementia(VaD)in the one year follow up.Serum FAM19A5 and IL-34 levels were measured by enzyme linked im-munosorbent assay.The factors of VCIND progression to VaD were analyzed by multifactorial logistic regression,and the predictive energy efficiency of serum FAM19A5 and IL-34 levels on the progression of VCIND to VaD was analyzed by ROC curve.Results Compared with the control group,serum FAM19A5 levels were increased and IL-34 levels were de-creased in the VCIND group(t=19.808,15.706,all P＜0.001).At 1 year follow up,the incidence of VaD in 125 VCIND pa-tients was 36.00％ (45/125).Serum FAM19A5 levels were increased and IL-34 levels were decreased in the VaD subgroup compared with the non-VaD subgroup(t=7.100,5.952,all P＜0.001).Increased age(OR=1.137,95％ CI:1.014 to 1.275)and elevated FAM19A5(OR=1.079,95％ CI:1.040 to 1.119)were independent risk factors for progression of VCIND to VaD,and increased Montreal Cognitive Assessment Scale score(OR=0.603,95％ CI.0.437 to 0.832)and elevated IL-34(OR=0.737,95％ CI:0.624 to 0.870)were independent protective factors(P＜0.05).The area under the curve for the combined prediction of VCIND progression to VaD by serum FAM19A5 and IL-34 levels was 0.880,which was greater than the 0.813 and 0.781 predicted by serum FAM19A5 and IL-34 levels individually(t=2.529 and 2.855,all P＜0.05).Conclusion Elevated serum FAM19A5 levels and decreased IL-34 levels were strongly associated with the progression of VCIND to VaD,and the com-bination of serum FAM19A5 and IL-34 levels had high predictive efficacy for the progression of VCIND to VaD.
关键词
血管性认知障碍/序列相似家族19成员5/白介素-34/预测价值
Key words
Vascular cognitive impairment/Family with sequence similarity 19 member 5/Interleukin 34/Predictive value
维普
万方数据