Objective To investigate the effect of Xuebijing in treating N methyl D aspartate receptor(NMDAR)encephalitis and the changes of helper T cell 1(Th1)/Th2 immune response.Methods One hundred and twenty patients with anti-NMDAR encephalitis admitted to the Department of Neurology of the Second Affiliated Hospital of Hainan Medi-cal University from January 2021 to December 2023 were selected and divided into observation group(60 cases)and control group(60 cases)by random number table method.The control group was treated with plasma exchange,and the observa-tion group was treated with Xuebijing on the basis of the control group.The course of treatment was 10 days.The clinical efficacy,mental improvement and symptom improvement time,relevant cytokine levels,prognosis and overall incidence of adverse reactions,changes in T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),Th1[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)]and Th2[interleukin-6(IL-6),interleukin-4(IL-4)]before and after treatment were compared between the two groups.Results There was no significant difference in clinical efficacy between the two groups(P＞0.05).The time of mental improvement and symptom improvement in the observation group was shorter than that in the control group(t/P=3.935/＜0.001,3.720/＜0.001).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group(t/P=3.017/0.003,5.062/＜0.001,3.211/0.002).After treatment,the levels of IFN-y,TNF-α and IL-6 in the observation group were lower than those in the control group,and IL-4 was higher than that in the control group(t/P=4.911/＜0.001,4.489/＜0.001,3.289/0.001,4.191/＜0.001).There was no statistically significant difference in prognosis and total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Xuebijing can effec-tively improve symptoms and regulate immune function in patients with anti-NMDAR encephalitis,which may be related to the improvement of Th1/Th2 balance,and the safety is good.
Anti-N methyl D aspartate receptor encephalitisXuebijingHelper T cellsImmune function
维普
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