Objective To investigate the features of vascular endothelial growth factor(VEGFs)and matrix metallo-proteinase(MMPs)concentrations in postoperative individuals with intracranial aneurysms and their prognostic predictive value.Methods During the period from December 2021 to December 2023,a total of 121 patients diagnosed with intracrani-al aneurysms were enrolled in our hospital and categorized into either the favorable prognosis group(n=92)or the unfavor-able prognosis group(n=29).Comparative analyses were conducted to explore the distinctions in general clinical character-istics as well as the levels of serum VEGFs and MMPs expressions between these two groups.The study utilized Spearman correlation test and binary Logistic regression analysis to discover the potential risk factors linked to unfavorable postopera-tive results in individuals diagnosed with intracranial aneurysms.Moreover,the effectiveness of these risk factors in predic-ting the probability of an unfavorable postoperative outcome was evaluated through the receiver operating characteristic(ROC)curve analysis.Results The average serum levels of VEGF-1,VEGF-2,MMP-1,MMP-2,and MMP-9 were also sig-nificantly elevated in the poor prognosis group compared to the good prognosis group(t/P=4.455/＜0.001,3.982/＜0.001,4.848/＜0.001,5.702/＜0.001,5.144/＜0.001).Spearman correlation analysis revealed a positive correlation between age,diabe-tes mellitus,and serum levels of VEGF-1,VEGF-2,MMP-1,MMP-2,and MMP-9 with poor prognosis among postoperative patients with intracranial aneurysms(r/P=0338/＜0.001,0361/＜0.001,0383/＜0.001,0386/＜0.001,0331/＜0.001).Addition-ally,multivariate Logistic regression analysis indicated that serum VEGF-1,VEGF-2,MMP-1,MMP-2,and MMP-9 were iden-tified as pivotal risk factors for poor prognosis in patients with intracranial aneurysms post operation[OR(95％ CI)=1.142(1.011-1.372),1.126(1.004-1276),1.027(1.002-1.052),1.029(1.006-1.052),1.026(1.006-1.047)].The AUC values for ser-um VEGF-1,VEGF-2,MMP-1,MMP-2,MMP-9 levels independently predicting poor prognosis in patients after intracranial aneurysm surgery were 0.729,0.744,0.759,0.761,and 0.724 respectively,with a combined prediction AUC of 0.890.The effica-cy of the combined prediction was greater than that of each individual marker(Z/P=4.344/＜0.001,4.185/＜0.001,4.013/＜0.001,4.010/＜0.001,4.350/＜0.001).Conclusion The correlation between serum VEGFs and MMPs expression levels in postoperative intracranial aneurysm patients and poor prognosis is significant.Developing a predictive model incorporating these markers holds clinical importance in early assessment and prompt intervention for this patient population,ultimately enhancing outcomes.Furthermore,such a model represents a promising biological target for future therapeutic strategies.
维普
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