Objective To investigate the correlation between serum levels of CC chemokine ligand 18(CCL18)and soluble triggering receptor expressed on myeloid cell 1(sTLT-1)in patients with coronary heart disease and the severity of coronary artery disease.Methods From June 2022 to June 2023,110 patients with coronary heart disease who underwent percutaneous coronary angiography Department of cardiology,the First Affiliated Hospital of Henan University of Science and Technology were gathered as the coronary heart disease group,the SYNTAX score was applied to assess the severity of coronary artery disease,and patients were separated into mild subgroup(54 cases),moderate subgroup(37 cases),and severe subgroup(19 cases),Another 110 cases of health checkups in hospitals in the same period were selected as the healthy control group.Enzyme linked immunosorbent assay(ELASA)was applied to detect the expression levels of serum CCL18 and sTLT-1;Spearman method was applied to analyze the correlation between serum CCL18,sTLT-1 levels and the severity of coronary artery disease;Logistic regression was applied to analyze the influencing factors of the severity of cor-onary artery disease;receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum CCL18 and sTLT-1 levels for moderate to severe coronary artery disease.Results The serum levels of CCL18 and sTLT-1 in the coronary heart disease group were obviously higher than those in the control group(t/P=7.505/＜0.001,8.537/＜0.001).As the degree of coronary artery disease increased,serum CCL18 and sTLT-1 levels increased sequentially in the mild,moderate,and severe subgroups of patients with coronary artery disease(F/P=24.542/＜0.001,28.067/＜0.001).There was a positive correlation between serum CCL18,sTLT-1 levels and both with the severity of coronary artery lesions(r/P=0.486/＜0.001,0.391/＜0.001).Multifactorial Logistic regression analysis showed that elevated CCL18 and elevated sTLT-1 were independent risk factors for the severity of coronary artery lesions[OR(95％ CI)=2376(1.169-4.830),2.695(1.494-4.862)];the AUCs of serum CCL18 and sTLT-1 levels and the combination of the two for the diagnosis of moderate to se-vere coronary artery disease were 0.748,0.721,and 0.813,respectively,and the AUCs of the combination of the two were greater than the AUCs of serum CCL18 and sTLT-1,each of which was diagnosed alone(Z/P=2.139/0.032,2.248/0.025).Conclusion Serum CCL18 and sTLT-1 levels were significantly elevated in patients with coronary artery disease,and both were associated with the severity of coronary artery lesions.
Coronary heart diseaseCC chemokine ligand 18Soluble triggering receptor expressed on myeloid cell 1Coronary artery diseaseCorrelationPredictive value
维普
万方数据
