Objective To investigate the levels and significance of serum interleukin 19(IL-19),vasohibin-1(VASH-1),neutrophil-to-lymphocyte ratio(NLR)in type 2 diabetic nephropathy(T2DN).Methods 100 patients with T2DN who were treated in our hospital from December 2020 to December 2022 were selected as the T2DN group,and 100 patients with type 2 diabetes mellitus(T2DM)alone were collected as the T2DM group.The levels of serum IL-19,VASH-1,and NLR were compared among the two groups,and the predictive value of serum IL-19,VASH-1,and NLR for DN was analyzed.Results The serum levels of IL-19,VASH-1,and NLR in the T2DN group were significantly higher than those in the T2DM group(t/P=8.347/＜0.001、8.277/＜0.001、8.762/＜0.001).According to binary Logistic regression analysis,high IL-19,VASH-1,and NLR are risk factors for T2DN[OR(95％ CI)=1.120(1.037-1.210),1.006(1.001-1.012),2.586(1.165-5.740),P＜0.05].Receiver operating characteristic(ROC)curve analysis showed that,The area under the curve(AUC)of serum IL-19、VASH-1、NLR and their combined prediction of T2DN were 0.807,0.799,0.822,0.854,respectively.The Yoden indices were 0.520,0.490,0.550,0.740.The sensitivity and specificity corresponding to the optimal critical values of IL-19 was 0.940 and 0.580,VASH-1 was 0.660 and 0.830,and NLR was 0.920 and 0.630,respectively.The combined sensitivity and specificity of the three meth-ods was 0.860 and 0.880.Conclusion The serum IL-19,VASH-1,and NLR of T2DN patients are increased,and the combi-nation of serum IL-19,VASH-1,and NLR has high predictive value for T2DN.
Type 2 diabetic nephropathyInterleukin-19Vasohibin-1Neutrophil lymphocyte ratioDiagnostic value
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