Objective To explore the evaluation value of geriatric nutritional risk index(GNRI),neutrophil to lym-phocyte ratio(NLR)and fibrinogen to albumin ratio(FAR)for prognosis of patients with advanced gastric cancer after radi-cal gastrectomy.Methods A retrospective analysis was performed on the clinical data of 115 elderly patients with gastric cancer undergoing radical gastrectomy in Western Theater Command General Hospital of the PLA between January 2020 and January 2022.The general data were analyzed,including age,gender,TNM staging,tumor size,tumor differentiation,depth of tumor invasion and lymph node metastasis.The levels of preoperative GNRI,NLR and FAR were detected.After 1-3 years of follow-up,relationship between GNRI,NLR,FAR and prognosis was analyzed by univariate analysis and Kaplan-Meier survival curves,and influencing factors of prognosis were analyzed by COX proportional hazard regression analysis.Results The levels of GNRI,NLR and FAR were correlated with gender,age,tumor diameter,TNM staging and lymph node metastasis(GNRI:t/P=54308/＜0.001,31.021/＜0.001,27.002/＜0.001,17.573/＜0.001,11.376/＜0.001,37.377/＜0.001;NLR:t/P=26364/＜0.001,16.017/＜0.001,10.702/＜0.001,10.106/＜0.001,8.084/＜0.001;FAR:t/P=4.154/＜0.001,5.091/＜0.001,3.776/＜0.001,5.564/＜0.001).The results of Kaplan-Meier curve analysis showed that overall survival rate and pro-gression-free survival rate in high GNRI group were higher than those in low GNRI group.The survival rate and progres-sion-free survival rate in low NLR group and low FAR group were higher than those in high NLR group and high FAR group,respectively(P＜0.05).COX proportional hazard regression analysis showed that TNM staging at stage Ⅲ-Ⅳ,lymph node metastasis,high levels of NLR and FAR were risk factor affecting progression-free survival,while high level of GNRI was a protective factor[OR(95％ CI)=1.933(1.227-3.046),2.396(1.293-4.443),2.606(1.381-4.919),2.754(1.494-5.076),0297(0.098-0.894)].Conclusion In patients with advanced gastric cancer,level of preoperative GNRI is low,while levels of NLR and FAR are high.The three indexes are related to clinicopathological characteristics and prognosis of patients.
Advanced gastric cancerRadical gastrectomyGeriatric nutritional risk indexNeutrophil to lympho-cyte ratioFibrinogen to albumin ratioPrognosis
维普
万方数据
