Transmembrane emp24 domain-containing protein(TMED)family,as a kind of transmembrane protein whose molecular weight is 24KDa,plays important roles in many aspects,such as early embryonic development,organ for-mation,innate immune signaling,cell proliferation and so on.In recent years,people have focused a lot on researches appli-cations of TMED family in treating malignant tumor and its abnormal expressions are closely related to the occurrence,de-velopment,invasion,metastasis and prognosis of tumors.Recent researches have shown that TMED has expressions of dif-ferent degrees in different malignant tumors,including breast cancer,liver cancer,ovarian cancer,colorectal cancer,cervical cancer,etc.It has a very complex mechanism in promoting tumor development.This thesis discusses the current research situations of the application of TMED in treating malignant tumors and its operational mechanism,contributing to the groundwork for the prevention and treatment.
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