In recent years,the incidence of some neurological diseases such as Alzheimer's disease,depression and schizophrenia have increased significantly,which has attracted some scholars'attention.Subsequent studies have found that androgens may have protective effects on male nerve cells such as reducing inflammation and anti-oxidative stress.In addition,some clinical trial results also show that androgens can improve cognitive function and alleviate depressive symp-toms in some neurological diseases,such as male Alzheimer's disease and depression.Therefore,scholars have explored the possible neuroprotective mechanism of androgens in males.This article reviews the research progress of androgens on the neuroprotective mechanism of males.