Study on the correlation between cardiac function and blood uric acid,intestinal flora and miR-25 level in elderly pa-tients with chronic heart failure
Objective To investigate the relationship between cardiac function and serum uric acid,intestinal flora and miR-25 level in elderly patients with chronic heart failure.Methods A total of 110 elderly CHF patients admitted to the Second Department of Geriatric Medicine in the Third Hospital of Shijiazhuang from February 2021 to February 2024 were se-lected as the CHF group,according to the New York Heart Association(NYHA)cardiac function classification,the patients were divided into Grade Ⅱ(44 cases),grade Ⅲ(37 cases),and grade Ⅳ(29 cases).Another 110 healthy subjects were select-ed as the control group.The correlation of serum uric acid,intestinal flora,miR-25 level and cardiac function grade in elderly patients with CHF was analyzed by Pearson method.Multivariate Logistic regression was used to analyze the influencing factors of CHF in elderly patients.The value of serum uric acid,intestinal flora and miR-25 levels in the diagnosis of CHF in the elderly was analyzed by receiver operating characteristic(ROC)curve.Results Serum uric acid and miR-25 in chronic heart failure group were higher than those in control group,bifidobacterium and Lactobacillus were lower than those in con-trol group(t/P=8.993/＜0.001,9.656/＜0.001,9.516/＜0.001,6.542/＜0.001).The levels of serum uric acid and miR-25 in NY-HA elderly CHF patients with cardiac function in grade Ⅳ＞Grade Ⅲ＞Grade Ⅱ were compared(F/P=3.524/0.033,11.062/＜0.001).The comparison of Bifidobacterium and Lactobacillus showed that NYHA elderly CHF patients with cardiac func-tion in grade Ⅳ＜grade Ⅲ＜grade Ⅱ(F/P=10.008/＜0.001,37.612/＜0.001).Pearson correlation analysis showed that blood uric acid and miR-25 were positively correlated with cardiac function classification(r/P=0.528/＜0.001,0.482/＜0.001),while bifidobacterium and Lactobacillus were negatively correlated with cardiac function classification(r/P=-0.466/＜0.001,-0.474/＜0.001).Multivariate Logistic regression analysis showed that high blood uric acid and high miR-25 were in-dependent risk factors for the onset of CHF in elderly patients[OR(95％CI)=1.721(1.339-5.182),1.381(1.151-3.221)].Bifidobacteria high and Lactobacillus high were independent protective factors[OR(95％CI)=0.971(0.957-0.985),0.952(0.940-0.988)].The AUC of serum uric acid,bifidobacterium,Lactobacillus,miR-25 and the four combined in the diagnosis of elderly CHF were 0.780,0.773,0.675,0.822,0.936,respectively,and the AUC of the four combined was greater than the di-agnostic efficacy of each alone(Z/P=5.259/＜0.001,5.319/＜0.001,7.157/＜0.001,4.883/＜0.001).Conclusion Serum uric acid,intestinal flora and miR-25 levels are related to the severity of cardiac function in elderly patients with chronic heart fail-ure,and the combined detection of these indicators has high predictive efficacy for chronic heart failure.
维普
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