Gastrointestinal stromal tumor is the most common mesenchymal tumor,and surgical resection is the main method to treat localized gastrointestinal stromal tumor.Currently,several generations of tyrosine kinase inhibitors have been clinically developed to target the pathological mutations of gastrointestinal stromal tumors,all of which have a-chieved certain results.However,resistance to tyrosine kinase inhibitors often develops after 2-3 years of treatment,leading to treatment failure.In recent years,niclosamide has appeared in the public eye as a drug with anti-tumor activity.Due to its poor solubility and other reasons,crystal preparations have emerged to better exert its anti-tumor properties.This article combines the current experimental basis and related mechanisms to explore the possibility of combined administration in gas-trointestinal stromal tumors resistant to tyrosine kinase inhibitors,with a view to developing new treatment options for gas-trointestinal stromal tumors.
Gastrointestinal stromal tumorTyrosine kinase inhibitorNiclosamideMechanisms of resistanceCombination therapy
维普
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