Correlation between serum CXCLs,MMPs and inflammatory markers in peripheral blood of patients with primary liver cancer and short-term prognosis after treatment
Objective To explore the correlation between serum C-X-C chemokine ligand(CXCLs),matrix metallo-proteinase(MMPs),peripheral blood inflammation and short-term prognosis in patients with primary liver cancer.Methods One hundred and seventeen patients diagnosed with primary liver cancer at our hospital between September 2021 and September 2023 were categorized into two cohorts based on their short-term prognosis:a cohort with optimistic short-term prognosis(n=90)and a cohort with unfavorable short-term prognosis(n=27)within 3 months post-treatment.Various pa-rameters including general clinical characteristics,levels of CXCLs(CXCL2,CXCL8,CXCL9,CXCL13),levels of MMPs(MMP-2,MMP-7,MMP-9,MMP-14),and peripheral blood inflammatory markers[neutrophil/lymphocyte ratio(NLR),lym-phocyte/monocyte ratio(LMR),and systemic immune inflammation index(SII)]were measured and compared between these two groups.Spearman correlation analysis was used to analyze the correlation between differential indicators and poor short-term prognosis after treatment in patients with primary liver cancer;multivariate Logistic regression analysis was used to analyze the influencing factors of poor short-term prognosis after treatment in patients with primary liver cancer.Results The levels of serum CXCL8,CXCL9,and CXCL13 in the poor short-term prognosis group were higher than those in the good short-term prognosis group(t/P=3.876/＜0.001,4.779/＜0.001,5.434/＜0.001);the levels of serum MMP-2,MMP-7,MMP-9,and MMP-14 in the poor short-term prognosis group were higher than those in the good short-term prognosis group(t/P=6.775/＜0.001,5.376/＜0.001,6.377/＜0.001,6.565/＜0.001);the SII in the poor short-term prognosis group was higher than that in the good short-term prognosis group(t/P=5.569/＜0.001);Spearman correlation analysis showed that tumor diameter,multiple tumors,cirrhosis,CXCL8,CXCL9,CXCL13,MMP-2,MMP-7,MMP-9,MMP-14,and SII were posi-tively correlated with poor short-term prognosis after treatment in patients with primary liver cancer(r=0.286,0.209,0.200,0.415,0.417,0.420,0.459,0.383,0.493,0.442,0.440,all P＜0.05);the results of multivariate Logistic regression analysis showed that high levels of serum CXCL8,CXCL9,CXCL13,MMP-2,MMP-7,MMP-9,MMP-14,and high SII were independent risk factors for poor short-term prognosis after treatment in patients with primary liver cancer[OR(95％CI)=1.021(1.009-1.063),1.043(1.006-1.082),1.087(1.011-1.170),1.455(1.045-2.026),1.096(1.001-1201),1.027(1.011-1.074),1.128(1.083-1.295),1.044(1.024-1.066)].Conclusion The short-term prognosis of patients with primary liver cancer with high levels of serum CXCLs,MMPs,and SII is often poor after treatment.Closely monitoring the changes in serum CXCLs,MMPs levels,and SII has certain clinical significance for accurately assessing the prognosis of patients with primary liver cancer.
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